Results were announced from the pivotal EAGLE-1 phase 3 trial, showcasing gepotidacin as a potential oral antibiotic with a mechanism of action aimed at treating uncomplicated urogenital gonorrhea in adolescents and adults. The study achieved its primary efficacy goal, with two 3,000mg oral doses of gepotidacin showing non-inferiority to a standard treatment regimen of 500mg intramuscular ceftriaxone plus 1,000mg oral azithromycin. This is drawn from the primary endpoint, which is the microbiological response, measured as either success or failure, at the Test-of-Cure (ToC) visit occurring 3-7 days following treatment.
Gepotidacin disrupts bacterial DNA replication through a mechanism of action and binding site, effectively inhibiting 2 distinct Type 2 topoisomerase enzymes in a balanced manner. This balanced inhibition contributes to its effectiveness against a wide range of target uropathogens, including E coli, S saprophyticus, and Neisseria gonorrhoeae, even those strains that have developed resistance to existing antibiotics. For resistance to significantly impact gepotidacin’s effectiveness, mutations targeting both enzymes are required, highlighting its action against these pathogens.1
Main Takeaways
The EAGLE-1 phase 3 trial has substantiated gepotidacin’s clinical equivalence to the established treatment regimen for uncomplicated urogenital gonorrhea.
Gepotidacin introduces a novel approach to bacterial DNA replication inhibition, offering a strategic advantage in the global effort to combat antibiotic-resistant gonorrhea strains.
The development and ensuing success of gepotidacin in clinical trials represent a pivotal response to the escalating public health challenge posed by gonorrhea, particularly strains resistant to current therapies.
When the gepotidacin phase 3 trial clinical program launched in 2019, Hal Baron, MD, chief scientific officer and president of research and development at GSK said in the company’s statement, “Given the increasing rate of antibiotic drug resistance, and gepotidacin’s unique mechanism of action, we believe this drug has the potential to transform the treatment landscape for patients with urogenital gonorrhea who currently have limited therapeutic options.”2
“CDC estimates that approximately 1.6 million new gonococcal infections occurred in the United States in 2018, and more than half occur among young people aged 15-24.1 Gonorrhea is the second most commonly reported bacterial sexually transmitted infection in the United States,” according to the CDC. “Gonorrhea is a sexually transmitted disease (STD) caused by infection with the N gonorrhoeae bacterium. N gonorrhoeae infects the mucous membranes of the reproductive tract, including the cervix, uterus, and fallopian tubes in women, and the urethra in women and men. N gonorrhoeae can also infect the mucous membranes of the mouth, throat, eyes, and rectum.”3
This breakthrough is noteworthy considering the growing concern on the emergence of antibiotic resistance in N gonorrhoeae. This concern is underscored by the identification of the penA 60.001 allele in N gonorrhoeae, a specific genetic variation that contributes to this type of antibiotic resistance. The penA 60.001 allele alters the bacterial response to cephalosporins, a key class of antibiotics for treating gonorrhea.4
“Due to high rates of gonorrhea, rapid evolution of N gonorrhea resistance, and increasing case reports of penA 60.001 allele associated with treatment failures, US patients with failed treatment for gonorrhea might be anticipated in the near future. Although ceftriaxone was still effective, these primary care cases are a warning to clinicians and public health officials to scale up clinical awareness, surveillance, and laboratory detection, including culture and gradient strip antimicrobial susceptibility tests and advanced molecular diagnostics, to delay the arrival of extremely drug-resistant gonorrhea until new treatments or vaccines are developed.”4
All in all, the safety and tolerability of gepotidacin observed in the EAGLE-1 phase 3 trial aligned with the outcomes from earlier phase 1 and 2 trials of gepotidacin. Comprehensive findings from the EAGLE-1 trial are slated for presentation at a forthcoming scientific conference and will be communicated to health regulatory bodies worldwide.
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In my guide to the best stir fry pans, you’ll learn everything you need to know about the types of materials, pan shapes, and nonstick treatments. I even included one of all-time favorites, the GreenPan Ceramic Non-Stick Wok!
Credit: The Recipe Critic
The next time you’re craving Chinese food, don’t call for delivery! With one of the best stir fry pans, you can make a delicious noodle-based dish, complete with some essential ingredients you likely already have in your fridge, freezer, or pantry. Whether you opt for my easy veggie stir fry or my garlic chicken one, it’s a great way to use up leftover veggies and protein.
Ahead, check out all the details on the best stir fry pans and the qualities to look for when choosing one for your kitchen.
My Top Picks:
In My Kitchen: GreenPan Ceramic Coated Nonstick Wok Pan – $46.07 at Amazon
Best Enameled Cast Iron Stir Fry Pan: Lodge Enameled Cast Iron Skillet – $60 at Amazon
Best Non-Stick Stir Fry Pan: GreenPan Valencia Pro Ceramic Coated Fry Pan – $59.99 at Wayfair
Best Wok: Calphalon Signature Non-Stick Flat-Bottom Wok – $109.95 at Amazon
Best Budget Stir Fry Pan: Cuisinart Chef’s Classic Non-Stick Skillet – $37.53 at Amazon
The best pan to cook stir fry is one that has plenty of room for ingredients without overcrowding or sticking. I love the GreenPan brand because everything I’ve tried has been great quality, durable, and affordable, and this ceramic-coated, nonstick wok pan is no exception.
It’s safe to use with metal utensils, so you don’t have to worry about scratching the non-stick (and Teflon-free) surface — this is especially nice if you’re making your stir fry sauce in the pan and want to stir ingredients around!
My Tips:
This pan is metal-utensil safe, but to make sure the ceramic coating stays in great shape, I like to use silicone utensils. My favorites are the Chef Craft Spatula and Chef Craft Spoonula.
The Specs:
Dimensions: 11 inches
Weight: 2.22 pounds
Material: Anodized aluminum with ceramic non-stick coating, stainless steel handle
Heat sources: Gas, electric
Cleaning: Hand wash recommended, dishwasher safe
The Pros:
Easy to clean
Durable
Even heat
Non-toxic, nonstick coating
Oven-safe
The Cons:
Not induction-cooktop friendly
Buy the GreenPan Chatham Hard-Anodized Ceramic Non-Stick Wok Pan:
Cast iron is so versatile — you can whip up my amazing pepper steak stir fry to get the perfect seared edges or use it for an oven-baked skillet cookie, and the cast iron retains heat to keep ingredients warm. This super popular cast iron skillet from Lodge is a great pick thanks to its decent-sized diameter (11 inches) and versatility (it can go in the oven at up to 500˚F!).
It also has an enamel coating, so you don’t have to season it like a regular cast iron pan, which is a HUGE bonus if you’re someone who loves a low-maintenance pan. It’s also protected from rusting, but just make sure you hand wash it instead of popping it in the dishwasher.
The Specs:
Diameter: 11 inches
Weight: 7.67 pounds
Material: Enameled cast iron
Heat sources: Gas, electric, oven, induction
Cleaning: Recommended hand washing only
The Pros:
Great heat distribution and retention
Versatile
Easy to use
Oven-safe
Comes in two fun colors (blue or red)
The Cons:
Heavy
No non-stick coating
Hand wash only
What Others Are Saying:
This skillet has a 4.2-star rating from more than 900 Amazon shoppers.
I love my GreenPan wok, but a frying pan is just as great for preparing something like easy fried rice. With this popular ceramic-coated pick (the base is hard-anodized aluminum), you can easily spread all your ingredients out (think leftover rice, veggies, and your protein of choice) so they all get a little crispy without sticking to the pan. Yum! This pan can also be used with metal utensils and is oven-safe up to 600˚F.
The Specs:
Diameter: 11 inches
Weight: 1.34 pounds
Material: Hard-anodized aluminum with ceramic non-stick coating, stainless steel handle
Heat sources: Gas, electric, glass, induction
Cleaning: Dishwasher safe
The Pros:
Easy to clean
Heats quickly
Lightweight
Teflon-free coating
Multiple size options
The Cons:
High cooking temperatures can affect the ceramic coating
Not induction-cooktop friendly
What Others Are Saying:
This GreenPan pick was named the best non-stick ceramic fry pan by America’s Test Kitchen. It also received an award from Good Housekeeping for sustainable innovation.
Buy the GreenPan Valencia Pro Ceramic Non-Stick Fry Pan:
This wok from Calphalon is a nice investment piece for your kitchen. I love that the traditional, flat bottom design works well on electric stoves, which is especially great for quickly cooking up meals like my Korean Ground Beef Stir Fry.
The hard-anodized interior is super durable, too, while the non-stick coating will ensure every last ingredient ends up on your plate. It’s dishwasher-safe for easy cleaning, plus it comes with a glass lid so you can check your progress without letting essential heat out.
One of the best frying pans for stir fry is this skillet from Cuisinart. Beyond its affordable price point, it has features that compete with some of the more expensive picks on my list — for instance, the cool-grip handle, drip-free pouring design, and oven-safe design up to 500 ̊F. Like some of the other options I picked, the non-stick coating is titanium reinforced without PFOA or PTFE, so it’s free from chemicals.
Made of carbon steel, a common material for traditional woks, this flat-bottom pan is designed for both indoor and outdoor cooking, so you can whip up something tasty on the grill or even a campfire! It comes pre-seasoned, but like cast iron, it requires regular seasoning to keep it in good shape. This wok pan is also hand-wash only, so it generally requires a bit more upkeep than other pans. The Yosukata Flat Bottom Wok Pan is available on Amazon for $59.99.
This non-stick fry pan is compatible with gas, electric, glass, and induction stovetops. It’s also broiler-safe up to 500°F, so you can do a quick, crispy finish in the oven. Made by iconic cooking brand All-Clad, this pick is easy to use thanks to the helper handle for added stability, but customers reported the long handle is uncomfortable to hold onto. Also, this model uses a PTFE non-stick treatment that can release chemicals when scratched, so you should stick with silicone, nylon, or wood utensils. The All-Clad Hard-Anodized Non-Stick Fry Pan is available at Amazon for $99.95.
Cuisinart is pretty well known for its line of small kitchen appliances, but the brand has cookware, bakeware, cutlery, and other tools to round out your kitchen at affordable prices. This 12.5-inch pan is a great entry-level option, but it doesn’t rise above the rest as the best wok, especially because of its loftier price point. The Cuisinart Chef’s Classic Non-Stick Hard-Anodized Stir Fry Pan is available at Amazon for $69.99.
This enameled fry pan from Le Creuset is great for cooking everything from stir fry to scrambled eggs. It’s a lovely addition to the kitchen, but this pan is pretty expensive, and considering its mid-range reviews from other customers, it’s not clear that the value is there for the price. The Le Creuset Enameled Cast Iron Shallow Fry Pan is available at Williams Sonoma for $175.
This cast iron pan comes pre-seasoned and ready to work. It offers even heat distribution and is super versatile (cook stir fry AND skillet cookies), but it’s heavy and requires extra effort to maintain the seasoning for the best cooking results. The Lodge Bold Cast Iron Pan is available at Amazon for $49.90.
This 12-inch wok is compatible with electric, gas, and induction stovetops, is oven-safe up to 500°F, and has a laser-etched non-stick surface that is endorsed by celebrity chef Gordon Ramsay. Stainless steel has a tendency to stain, though, so even though it’s dishwasher safe, it may take some extra effort to keep it looking good. The HexClad Hybrid Stainless Steel Non-stick Wok is available at Walmart for $144.
Credit: The Recipe Critic
Why You Can Trust Me
My family and I love a good stir fry, and I always have the best time making them because I can use up any ingredients I have on hand to craft a tasty, healthy meal. Stir fry is a great way to get more vegetables in our diet, and the different flavor combinations are so fun to explore. We love adding proteins to our stir fry, too, so having the right pan to cook veggies and meats evenly is essential.
That’s what inspired me to research the best pans for stir fry — whether you want a traditional wok, a versatile skillet, or a handy frying pan, there are a ton of great options out there. When I began to narrow down my list of the best options, I took a look at some of the most popular brands and models, read through tons of customer reviews, and took some other factors into account, like size, material, and non-stick coating.
What to Know About Stir Fry Pans
Credit: The Recipe Critic
What to Consider Before Buying a Stir Fry Pan
There are a few things to keep in mind when purchasing a stir fry pan, like the size, material, weight, ease of cleaning, and type of heat source that it’s recommended for.
Size: If you’re cooking for one or two people, a smaller pan (8-10 inches) is a good diameter. But 12-14 inches will give you plenty of space to work without the pan feeling unwieldy if you’re cooking stir fry for a family or making big batches for leftovers.
Weight: Once loaded with ingredients, stir fry pans can feel heavy. Cast iron pans tend to be heavier than aluminum, and both often feature a helper handle to make it easier to manage the weight. Make sure you choose a stir fry pan that won’t be too heavy to maneuver while cooking.
Material: You’ll see pans made of hard-anodized aluminum, cast iron, carbon steel, and stainless steel. Stainless steel generally isn’t non-stick, so it’s not ideal for cooking stir fry unless you use a lot of oil. Meanwhile, carbon steel and cast iron often need to be seasoned between uses to maintain cooking performance, with the exception of enameled cast iron. Aluminum pans are generally the lightest option but have a bunch of different non-stick coatings. I prefer ceramic because it’s chemical-free, but it ultimately depends on what you like using in the kitchen!
Heat sources: Most pans will work with the average gas or electric stove. However, if you have an induction cooktop, you definitely need to look for a stir fry pan that’s designed for that.
Cleaning: Do you want to hand-wash your pan every time you use it, or do you like to be able to put it through the dishwasher? Some pans are dishwasher safe, but the manufacturers recommend hand washing to preserve the non-stick finish.
Credit: The Recipe Critic
What is the Difference Between a Wok and a Stir Fry Pan?
Wok: A wok is a round, deep, and wide bowl-shaped pan with a flat bottom designed to concentrate heat for searing ingredients, allowing you to cook a bit quicker. It’s also worth noting that a wok heats up and cools down rapidly, and it’s easy to overcrowd the ingredients, so it’s a bit harder to cook food evenly for home chefs who are new to using a wok.
Stir Fry Pan: A stir fry pan is flat and shallow with a wider bottom so that sauces can sit in an even layer. Woks and stir fry pans can both be used to make a great stir fry but may require some trial and error to ensure even cooking for the best results.
In general, if you’re new to cooking stir fry, I would recommend a stir fry pan instead of a wok.
What is the Best Material for Stir Fry?
The best material for a stir fry pan is something you’ll use regularly and gives you the results you’re looking for. If it requires special treatment that you’re not interested in doing, then you’re unlikely to reach for that pan.
Carbon Steel: Many chefs and cooks swear by carbon steel as the best material for stir fry because it’s lightweight and resilient, but it may also require extra effort — like seasoning and special washing instructions — to maintain the pan. Cast iron is also popular for stir fry because of its ability to retain heat, but like carbon steel, standard cast iron requires seasoning and careful washing. Enamel-coated cast iron is a bit easier to work with.
Hard-anodized aluminum: Hard-anodized aluminum has become popular with home chefs because it’s lightweight and durable. Anodized aluminum has undergone a process to make the material safe (it does not have health concerns as standard aluminum does), but also thicker and more durable to create a hard, non-stick, and scratch-resistant surface ideal for cooking stir fry.
Stainless Steel: Stainless steel is perfect for searing protein, cooking veggies, and making sauces, but starchy foods like noodles and rice can stick to it. This means you should be careful when tossing them in at the end of a recipe to coat them with the yummy sauce in your stir fry.
Credit: The Recipe Critic
What Kind of Pan is Best for Stir Fry?
By and large, chefs tend to prefer using a wok-style pan for stir fry because the tall sides make it easy to pull ingredients up and away from the concentrated heat at the bottom. There’s also plenty of room for stirring everything together without anything sloshing over the edge of the pan.
However, when your kitchen is short on storage, a standard skillet-style pan is sufficient for making stir fry. Just keep in mind how many people you’re cooking for and select the appropriate-sized pan so you have room to work.
How to Cook Chicken Stir Fry in a Pan
Heat pan with oil
Add aromatics like garlic, ginger, and chilis
Add longer-cooking ingredients like chicken (or other proteins)
Add shorter-cooking ingredients like broccoli, snow peas, or bell peppers
Add the sauce
Have noodles ready to toss in to coat or rice to serve on the side
Prep garnishes to top your stir fry, like sesame seeds or chopped green onion.
I love that stir fry can be a complete meal by itself, but I also love adding egg rolls, fruit salad, and cream cheese wontons on the side for a restaurant-style experience!
Feb. 28, 2024 – We know that we have to exercise. It boosts our cardiovascular health, strengthens muscles, and ultimately contributes to our longevity and quality of life. But according to new research, women may benefit more from physical activity than men do. Does that mean there should be sex-based guidelines around exercise?
It turns out, when it comes to recommending different exercises based on sex and gender, there isn’t an expert consensus.
Weight training, for example, should be an essential part of anyone’s exercise regimen. But it’s especially important for women to incorporate weight training into their routines, says Phillip Williams, MD, an orthopedic surgeon with Baylor College of Medicine, due in large part to their higher risk of osteoporosis as they approach menopause.
“Weight training improves bone density greater than any other type of exercise,” Williams says. “As an orthopedic surgeon, I definitely encourage any woman who might be at risk for osteoporosis to engage in a good weight training regimen where they’re challenging their muscles regularly.”
The current guidelines published by the U.S. Department of Health and Human Services recommend that weight training – also referred to as resistance training – should be incorporated into everybody’s routine at least twice a week.
There’s no specific amount of time given for muscle-strengthening exercises, but it’s suggested that you do one or two sets of 8-12 repetitions of the same movement. These sets can include bicep curls, deadlifts, bench presses, push-ups, etc.
The new study, published in the Journal of the American College of Cardiology, found that the rates of early death for women who exercise consistently decreased by up to 24%; for men who worked out the same amount, their rates of early death only decreased by 15%.
Though the earlier you start weight training, the better, it’s never too late to start, said Williams. The benefits of weight training, even more so for women, can still happen even if you’re just starting at 60 years old.
Although men don’t see as high of improvement rates in bone density through weight training as women do, Williams said, men withosteoporosis do see significant improvements from it.
Where men may fall short, in Williams’ experience, is in flexibility.
“Men typically suffer from ruptures of tendons from an exercise standpoint from not having enough flexibility, not stretching their tendons and muscles,” said Williams. “You see more ruptures of Achilles tendons, biceps tendons, and things like that in men because of the types of sports they engage in.”
That’s why men of all ages should experiment with exercises that are usually female-dominated – like yoga and Pilates. Male-dominated sports and forms of exercise typically incorporate “explosive movements,” but neglecting the stretching that yoga and Pilates can provide can be detrimental and lead to more muscle strains and ruptured tendons.
Many experts, however, follow the school of thought that all people, regardless of sex and gender identity, should follow the same core exercise routines.
“Everyone should want to hit all pillars of fitness, including strength training, endurance, aerobic exercise, flexibility, and balance,” said David Janke, an American College of Sports Medicine-certified exercise physiologist at the University of California San Francisco’s cardiac rehabilitation center. “That goes for men and women.”
The only difference Janke sees when it comes to sex-based differences in exercise is where men and women tend to hold their weight and muscle mass. Studies have shown that, on average, women tend to have a higher percentage of body fat than men; they also tend to store extra weight in their glutes, whereas men usually store extra fat in their abdominal region.
But even with that knowledge, there isn’t a lot of data to back up the efficacy of what many call “spot training,” or doing certain exercises to target “problem” areas on the body.
Janke has seen the same thing while working with people in recovery after cardiac events.
“Spot training, in my experience, doesn’t seem to benefit people – man or woman – as much as just focusing on doing all your muscle groups,” Janke said. He prescribes the same routines to everyone, no matter their sex or gender.
Use your own body weight: push-ups, squats, and lunges are all included under the weight training umbrella.
If you have free weights, like dumbbells or barbells, you can add in bicep curls, bench presses, deadlifts, and more. You can also add dumbbells to your body weight exercises for an extra challenge.
Weight machines may seem intimidating at the gym, but they aren’t as scary as they seem – as long as you listen to your body and research proper form. They can help you hit even more targeted muscle groups, with exercises like hamstring curls, chest presses, lateral pulldowns, and more.
Stretching: Making a simple stretching routine a staple of your pre- or post-workout regimen can be a game changer in helping you avoid injuries.
Yoga has it all when it comes to stretching, and you don’t need to pay for expensive classes, either. With online classes and YouTube tutorials, adding in weekly doses of yoga can provide the necessary amount of stretching you might be missing from your fitness routine.
Pilates: Much like weight machines in the gym, Pilates reformers can be intimidating at first. But you don’t have to start on the reformer; you can build up to that after practicing floor exercises on a mat. If you are able to get on a reformer, however, classes are the best option for fully understanding what the machine can do for your flexibility potential.
In today’s Centers for Disease Control and Prevention’s (CDC) ACIP group meeting, committee members voted to recommend that seniors 65 years and older receive an additional dose of the 2023-2024 formula COVID-19 vaccine.
Specifically, the ACIP committee voted on the following question:
ACIP recommends that person ≥ 65 years of age should receive an additional dose of the 2023-2024 formula COVID-19 vaccine.
The committee vote was 11-1 in favor of recommending the vaccine, and there was 1 voter who abstained.
This is a new recommendation for this year, and the CDC committee was presented with data and information showing this age group was more at risk for severe disease and mortality. People who are 65 years of age and older have the highest hospitalization rates. And despite the belief that COVID-19 has been declining, it is still claiming hundreds or thousands of people’s lives per week depending on that week’s incidence rates. According to the CDC, during its peak, approximately 2000 people were dying from COVID-19 weekly. More recently, incidence rates have fallen, but the numbers still show as many as 500 people per week are succumbing to COVID-19. People who are 75 years of age and older have the highest mortality rates.
Although there are increases of COVID-19 incidence rates during the respiratory virus season it does not have as sharp an increase or decline as other respiratory viruses such as RSV and influenza during the winter months.
Vaccine Efficacy
One of the more interesting aspects is the current vaccines’ efficacy (VE) vs their efficacy a few years ago when the vaccines were still investigational. One of the committee members had posed a question about the apparent drop in the VE.
“Context is so important,” said presenter Ruth Link-Gelles, PhD, CDC, commander, United States Public Health Service Commissioned Corps. In thinking about the vaccine from a historical perspective she explained no one had been exposed to the wild strain a few years ago. “The vaccine had the opportunity to protect absolutely. We are in a completely different place.”
Slideshow: Looking at Vaccine Efficacy
In thinking about it today where 98% of the US population has had either prior immunity via vaccination, prior infection, or both, Link-Gelles offered further insights. “It protects against future disease. It provides an additional benefit.”
Vaccine Coverage and Attitudes
During this morning’s session on COVID-19 and the vaccines, various CDC presenters offered insights on the latest data including vaccine coverage and attitudes about future vaccine immunization amongst the public.
In a survey conducted by CDC, 37%-42% said they would not get vaccinated. Females had a higher vaccination coverage at 23% and males were at 18%.
Interestingly, cardiovascular disease is the number 1 underlying medical condition for hospitalization in all adults 50 years and older. For those adults 18-48 years old, the biggest underlying medical condition was obesity. Possibly a bit surprising was that across all ages, chronic lung disease was not the highest reason for hospitalization, and in some groups not even second.
June Vaccine Policy Decision
CDC offered a new proposal with the idea of moving up the timeline for the annual COVID-19 vaccine schedule for the following season. The federal agency presenters said they wanted to move up the decision to June.
For 2023, the decision for the immunization schedule was made in the second half of the year. In their presentation, CDC pointed out that the COVID-19 vaccine schedule for this past year was voted on by ACIP on September 12, updated on September 27, and published in the MMWR on October 10.
Slideshow: How a June Deadline Impacts the COVID-19 Vaccine Schedule
The CDC presenters pointed out that on the week ACIP voted on the schedule last September, there was a COVID-19 surge with 19,895 hospitalizations, which was the second highest week of the year before a major uptick later in the fall and winter.
In addition, CDC pointed out several potential negative impacts for keeping the current timeline in place including less lead time in several areas including: for planning for the vaccine schedule, the possibility of a COVID-19 surge with hospitalizations not giving providers, facilities, and partners ample time to address the surge and mitigate the rise of disease, the inability of public health communication of the available vaccines and recommendations, and limited capability to set up vaccination clinics.
With a June deadline, CDC pointed out there would be several advantages in addressing these aforementioned issues.
This website may contain affiliate links and advertising so that we can provide recipes to you. Read my disclosure policy.
Outrageously wonderful Cruffins are made with just 4 ingredients for a sweet brunch treat that is loved by all! These tender, buttery pastries are made with crescent roll dough rolled up with a cinnamon-sugar mixture and baked until they’re fluffy and soft!
If you love these cozy cruffins, then you will want to try all of our incredible pastry recipes! Try out my favorite Cinnamon-Sugar Donut Muffins, these Boston Cream Donuts or these flakey, fried Cronuts for your next breakfast spread.
What are Cruffins?
If you’ve never tried Cruffins, get ready to be blown away! They are a cross between a croissant and a muffin. You will go crazy for all the tender layers of a croissant rolled up and cooked in a muffin pan, so these bake up in the shape of a muffin. Cruffins are also similar to cinnamon rolls since the dough is buttered and rolled up with a mix of cinnamon and sugar. They are perfectly sweet, buttery, and over-the-top irresistible!
This Cruffins recipe is not only delicious but also SO easy because instead of making the dough from scratch, you use crescent roll sheets from a tube! With just 4 ingredients, these are so simple that even the most beginner of bakers can create this masterpiece of cinnamon sugar deliciousness!
Ingredients Needed
The four ingredients needed to make cruffins are ones that you probably have in your kitchen right now! These look fancy enough for a special occasion or a holiday brunch, but they’re easy to make anytime. Check out the recipe card at the bottom of the post for all of the exact ingredient measurements.
Ground Cinnamon: For that warm, cozy flavor that is just so delightful.
Granulated Sugar: Mixed with cinnamon, granulated sugar gives these cruffins the perfect amount of sweetness.
Crescent Roll Sheets: Using crescent roll sheets from a tube makes this recipe super easy and fuss-free!
Salted Butter: Softened butter helps the cinnamon and sugar adhere to the dough and gives these the best buttery taste.
How to Make Cruffins
These cruffins are simple to make because you use ready-to-go crescent roll dough from a tube. Here’s how they come together:
Prep
Prep: Preheat the oven to 350 degrees Fahrenheit. Spray a muffin pan well with pan spray, I recommend using a baking spray that has flour in it, like Baker’s Joy.
Combine Cinnamon and Sugar: In a medium bowl, mix the cinnamon and sugar and set aside.
Add Filling: Roll out each tube of crescent roll dough until it is a 14×10-inch rectangle. Spread 3 tablespoons of softened butter evenly over each sheet of dough. Sprinkle ¼ cup of the cinnamon sugar mixture over each sheet and spread it until it is even.
Roll the Dough: Tightly roll each sheet up into a long along the long side, pulling the dough taut as needed. Cut the logs in half, so you have 6 short logs. Slice each in half lengthwise, which will expose the layers inside. Carefully roll each split portion starting on one end, keeping the sliced layers facing up. It will look messy, but it will create a pinwheel-looking roll of dough. Pinch the exposed end to the side it touches and place it in a well of the prepared muffin pan. Repeat with the remaining dough until you have 12 cruffins.
Bake
Bake: Place in the oven and bake for 20-25 minutes until the centers are fully baked and the edges have turned a deep golden brown. The baking time may differ slightly, depending on your oven. If the center still looks gooey or doughy, bake for a minute or two longer.
Roll in Cinnamon Sugar: As soon as the cruffins are done baking, carefully remove them from the muffin pan and immediately roll them in the remaining cinnamon sugar. Don’t let them sit in the pan! They will be very hot, so be careful, but if they start cooling at all in the muffin pan, they will become increasingly difficult to get out of the pan, and the cinnamon sugar won’t stick to them.
Cool and Enjoy! Let them cool for 10-15 minutes before serving.
Tips and Variations
Anyone who tries these cruffins will immediately fall in love with them! These are great for a special occasions, or just to have fun experimenting in the kitchen. Here are a few tips to help if you are making these for the first time!
Dough: If you can’t find crescent roll sheets, use regular crescent rolls and pinch together the seams.
Different Spices: For variation in flavor, try adding ¼-½ of nutmeg, cloves, and ginger in addition to the cinnamon. This will make your cruffins taste like fall!
Storing Leftovers
It’s best to serve your cruffins immediately. If you try to make them ahead of time, the cinnamon sugar will begin to weep in the refrigerator. The cruffins will stay good in an airtight container at room temperature for up to 3 days.
More Delicious Pastry Recipes
Pastries are so scrumptious and versatile because you can have them for breakfast, dessert or as a snack. Once you try making these recipes at home and realize just how amazing homemade pastries taste and how easy they can be, you will never need to go to the bakery again!
Preheat the oven to 350 degrees Fahrenheit. Spray a muffin pan well with pan spray, I recommend using a baking spray that has flour in it, like Baker’s Joy.
In a medium bowl, mix the cinnamon and sugar and set aside.
Roll out each tube of crescent roll dough until it is a 14×10-inch rectangle. Spread 3 tablespoons of softened butter evenly over each sheet of dough. Sprinkle ¼ cup of the cinnamon sugar mixture over each sheet and spread it until it is even.
Tightly roll each sheet up into a long along the long side, pulling the dough taut as needed. Cut the logs in half, so you have 6 short logs. Slice each in half lengthwise, which will expose the layers inside. Carefully roll each split portion starting on one end, keeping the sliced layers facing up. It will look messy, but it will create a pinwheel-looking roll of dough. Pinch the exposed end to the side it touches and place it in a well of the prepared muffin pan. Repeat with the remaining dough until you have 12 cruffins.
Bake for 20-25 minutes, or until the centers are fully baked and the edges have turned a deep golden brown. The baking time may differ slightly, depending on your oven. If the center still looks gooey or doughy, bake for a minute or two longer.
As soon as the cruffins are done baking, carefully remove them from the muffin pan and immediately roll them in the remaining cinnamon sugar. Don’t let them sit in the pan! They will be very hot so be careful, but if they start cooling at all in the muffin pan, they will become increasingly difficult to get out of the pan and the cinnamon sugar won’t stick to them.
More than half of all American adults have at least one chronic health condition such as diabetes, heart disease, cancer, lung or kidney disease, or a chronic mental illness such as depression. A chronic condition lasts for more than a year and requires ongoing medical care. It may also limit your daily activities.
If you have a chronic health condition, it can be comforting to know that many other people do, too. But living with a chronic health condition can take a physical, psychological, and emotional toll on your health, especially if you have multiple chronic health conditions.
The Physical Health/Mental Health Connection
Having a chronic health condition is a risk factor for anxiety and depression. In fact, 51 percent of people living with Parkinson’s disease, 42 percent of people diagnosed with cancer, and 27 percent of people with diabetes have depression. Nearly one in five people who have had a heart attack or heart disease also have depression. Chronic health conditions can affect your attitude, mood, and sense of certainty about the future. They can also make you doubt what you’re capable of physically.
When people feel limited in their ability to participate in social or recreational activities, they often become reclusive, lonely, or hopeless. They might develop poor eating or sleeping habits, which worsens their health. It’s common for people to focus so much on their physical condition that they don’t get the mental health support they need.
“Chronic health conditions and mental health diagnoses often go hand in hand,” says Dr. Luz Ramos, Medical Care Director for Clinical Care Transformation at Independence Blue Cross. “When someone is dealing with these challenges, their low mental and physical states can create a negative cycle, making it harder to take care of their health.”
Overcoming Chronic Health Challenges
Living with a chronic health condition can be difficult, but you don’t have to face it alone. Most chronic health conditions, whether physical or mental, can be managed.
“Sometimes, the biggest challenge people face is knowing where to start and who to reach out to,” says Dr. Ramos. “The best place to start is with a primary care provider who can look at your chronic conditions and mental health hand in hand. They can send you to specialists for any follow-ups needed, and help you navigate through the complex health care system – both for physical and mental health needs.”
There are other ways people living with chronic health conditions can improve their well-being. The National Institute of Mental Health suggests the following:
Exercise regularly. Being active doesn’t have to mean training for a marathon or lifting heavy weights. Thirty minutes of walking every day can boost your mood and health.
Eat a balanced diet. Good food choices can improve energy, mood, and health outcomes.
Get enough sleep. Sticking to a regular sleep schedule and getting enough rest is important for your mental, physical, and emotional health. When you’re well-rested, you can take better care of yourself.
Practice gratitude. Reminding yourself daily about the things you are grateful for can have positive effects on your mental health.
Stay connected. Spending time with loved ones who provide emotional and practical support can improve your well-being.
Many hospitals and patient organizations also offer online or in-person support groups where people with the same health condition can share their experiences and find helpful resources as well as a sense of community. For some, it can also be meaningful and empowering to participate in fundraising walks, research advocacy, or other activities that support those affected by the condition.
“While living with chronic health conditions can be challenging, it’s important to understand that health and medical care should always focus on the whole person,” says Dr. Ramos. “Physical and mental health are connected, and by taking care of one, you can take care of the other.”
For resources on chronic health conditions, visit:
For more information about mental health, self-care strategies, and where to find help, visit ibx.com/knowyourmind.
By Dawn Brown, Director of the National Alliance on Mental Illness HelpLine Services, as told to Danny Bonvissuto
My son, Matthew, was rare in that he was diagnosed when he was 8 years old. Most often, schizophrenia manifests in the late teens or early 20s.
At 18, he had a psychotic break and required hospitalization. Eventually he found treatment that was effective, but it took quite a while.
Once we found something that seemed to address his symptoms on several levels, he became treatment-compliant, which means he’s taking his medication on schedule. But medication is a small part of the treatment plan. He’s also keeping his appointments with his psychiatrist and therapist and doing what he can to maintain his overall health and wellness.
He’s 38 now. He enjoys his life. He has friends. He has places he goes during the day that keeps him engaged with others. But it’s been a journey.
The most difficult part is when someone first begins to experience symptoms. It’s rocky. There will be many ups and downs. Over time it does get better. An engaged, informed loved one is often the best indicator of the outcome for a person with schizophrenia.
‘The Perfect Storm’
Very often when people begin to have symptoms, or when they have full-blown psychosis related to schizophrenia, they resist treatment. It’s the perfect storm. You have young adults coming into their own, they’re experiencing symptoms, people are throwing around labels, and they’re resistant to having a serious mental health condition.
For a parent or caregiver, this is a very difficult situation. They’re adults at 18 and can make decisions about going to the hospital or taking medication. As a parent, you lose the power to make them do these things.
Listen and Empathize
In terms of getting someone to engage in treatment, we advise family members to listen. Don’t just hear, but listen to what their experience is. Their reality is different than most people’s reality. I wouldn’t say you should agree with what they say if it’s delusional. But you can empathize.
If they think someone’s out to get them, you can say, “That sounds very scary. You must be very worried.”
That’s their reality. Imagine that it were true. That’s what your loved one believes.
Then listen for anything that might motivate them to get treatment. Many people with schizophrenia have trouble sleeping. Treatment will help them with their sleep cycles.
Maybe they want to get back to college. You can say, “I know you’d really love to go back to college, and that’s what I want for you, too. Let’s see what you can do to get back there.”
Work with them to achieve their goals — not what you want, but what they want.
Ideally, after you’ve listened and empathized, you get them to agree to some therapy. At that point you become what I call a recovery partner, working with your loved one to find solutions and help.
At First, Treatment Is Trial and Error
A lot of people stop treatment because honestly, the medication available for schizophrenia isn’t always effective. It can have horrible side effects and people lose hope, so they stop.
One of the side effects is obesity. If you have a young woman who’s being told she needs to take this medication and she gains 30 pounds in 3 months, she wants to stop. The voices have stopped. But within a week or two the voices are back and the cycle starts all over again.
It’s common to try different medications at the beginning of treatment. That was true of my son as well. He tried four or five antipsychotics that targeted the more active part of schizophrenia — the hallucinations. But when he found one that worked, it was almost like a light switch turned on in his brain.
Matthew has obesity and some other unpleasant side effects. But he also has the awareness that he needs the medication and that the side effects aren’t as bad as the psychosis itself. That’s a very mature place to be.
I offer people hope to keep looking and don’t settle. Always work in conjunction with a psychiatrist. And get the person with schizophrenia to sign Health Insurance Portability and Accountability Act (HIPAA) consent so the psychiatrist can work with other mental health professionals. It’s very likely that, over time, if you’re persistent in seeking treatment options, you’ll find something that works.
Explain What The Medications Do
People with schizophrenia should be fully aware and informed about anything they put in their bodies. Part of them being a participant in their treatment is understanding the pros and cons of any type of medication and how you hope it will affect them.
Positive Reinforcement
Once the medication has become effective and the symptoms have receded, you can have a conversation about it. “Remember last month when you were hearing voices and couldn’t sleep? Remember how scary and awful that was? Now that the medications are working, it’s a good thing. A really important step.”
It’s positive reinforcement. You’re reaching them on an intellectual level about what they’re doing and what results they’re seeing. They can think through cause and effect: I like the effect, so I’m going to keep doing this.
Taper Treatment if It’s Not Working
It’s never a good thing to abruptly stop treatment for schizophrenia. If they’re unhappy with their side effects, or if the medication isn’t effective, impress the importance of working with their psychiatrist.
These are powerful medications that change the chemical balance in their brain. You might have to taper down one medication and work another into the regimen so your blood levels are sufficient. You want to avoid extremes, and don’t want to be completely knocked out.
Respectfully listen to why they want to stop and look for alternatives. There are a lot of combinations of options out there. It takes patience with the process to find the ones that work. They don’t work immediately: It takes a couple of weeks. Talk about what will be least disruptive to their life.
The HERO (Hepatitis C Real Options) study found that self-reported compliance with direct-acting antiviral (DAA) therapy for HCV treatment in persons who inject drugs (PWID) frequently exceeds adherence levels measured objectively. The study found that self-reported adherence to DAA therapy was notably higher than objectively measured adherence by an average of 19.2% among PWID. A threshold of more than 25% overreported adherence optimally predicted reduced sustained virologic response (SVR) rates. Identifying PWID at risk of significant overreporting may be crucial for implementing more targeted interventions to enhance adherence.
Average adherence rates were 95.1% (SD = 8.9) for self-reported, 75.9% (SD = 16.3) for objective, and a 19.2% (SD = 15.2) disparity between the 2. The threshold for overreporting was optimally set at more than 25%. SVR rates were significantly lower in the group with more than 25% overreporting compared to those with less than 25% overreporting (86.7% vs. 95.8%, p < .001). Factors linked to more than 25% discrepancy in adherence included unemployment, a higher frequency of drug injection, more positive drug screens for amphetamine, methamphetamine, and oxycodone, and fewer positive screens for THC (tetrahydrocannabinol)/cannabis.
“The findings of our study are consistent with some prior studies that measured objective adherence with electronic blister packs among PWID and studies that measured objective adherence using medication event monitoring system (MEMS) caps and pill counts among the general population treated for chronic HCV where self-reported adherence overestimated actual adherence,” according to the investigators. “Our estimate of 19.2% difference between the self-reported and the objective measures is comparable to the difference of approximately 17% estimated in a prior study.”
3 Key Takeaways
The study discovered that PWID’s self-reported adherence to DAA therapy was on average 19.2% higher than adherence levels measured objectively, pointing to a substantial overestimation of medication compliance among this group.
A threshold of more than 25% overreported adherence was identified as optimally predictive of reduced SVR rates, emphasizing the importance of accurate adherence measurement in achieving HCV cure.
Factors such as unemployment, higher frequency of drug injection, and specific drug use patterns were linked to higher discrepancies in adherence reporting.
The study analyzed data from 493 participants examining self-reported and objectively measured adherence to a 12-week course of DAA treatment. Adherence levels were assessed using visual analogue scales, for self-reported adherence, and electronic blister packs, for objective adherence. The difference between these 2 measures was calculated. An optimal threshold for overreporting that predicts lower SVR rates was established. Baseline characteristics were compared to identify factors associated with exceeding this threshold, by analyzing differences between participants who met or exceeded the threshold and those who did not.
“This is one of the first studies to focus on investigating how varying levels of discrepancy between self-reported and objective adherence measures relates to SVR,” according to the investigators. “While overreporting adherence is common, we have determined a threshold of overreporting that is predictive of significantly worse chances of achieving SVR; the validity of this threshold for predicting SVR should be tested further in future studies. By exploring the correlates of problematic levels of overreported adherence with respect to achieving the SVR outcome, our study also helps define the subpopulation of PWID with HCV who may benefit from additional adherence support.”
The study has several limitations, including its lack of generalizability due to population-specific factors and challenges of self-reported data, such as recall and social desirability biases. Methodological variations in adherence measurement across studies complicate direct comparisons, with this study employing electronic blister packs while others use different methods, affecting adherence rates and perceived discrepancies. The difficulty in identifying low actual adherence among individuals who report high levels of adherence. Additionally, the sample’s demographic composition, with low representation of women, minority groups, and rural populations, and small sample sizes for certain adherence categories.
All in all, healthcare providers might have to offer intensive support to PWID prone to overreporting to enhance adherence and increase the chances of SVR, directed towards issues like employment and facilitating connections to substance use treatments.
Reference
1. Lopes S, Pericot-Valverde I, Lum P, Taylor L, Mehta S, et. Al. Overreporting of Adherence to Hepatitis C Direct-Acting Antiviral Therapy and Sustained Virologic Response Among People Who Inject Drugs in the HERO Study. BMC Infectious Diseases. Published February 23, 2024. Accessed February 27, 2024. https://doi.org/10.1186/s12879-024-09124-3
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Rich, chewy, and topped with a dusting of powdered sugar, these gooey butter cookies are every cookie lover’s dream! You only need a handful of simple ingredients to make them. Give them a try and watch them fly off the table!
If there’s one recipe that’s worth breaking your diet for, it’s gooey butter cookies. These cookies are everything I say and more. Super easy to make, but even easier to devour with their AMAZING taste and texture.
These gooey butter cookies are made with all of the best ingredients. Cream cheese, powdered sugar, yellow cake mix for easy prep, and of course- all the butter. They’re tender, rich, and absolutely irresistible.
Ingredient List
Mix up all of these simple ingredients to get the most rich and gooey cookies out there! All measurements are in the recipe card below.
Cream Cheese: At room temperature so it mixes together smoothly with the other ingredients.
Powdered Sugar: Divided, you’ll use some for the cookies themselves and also for dusting on top.
Unsalted Butter: Again, at room temperature so you get a smooth cookie dough.
Vanilla Extract: For a little extra flavor. I recommend using pure vanilla extract for the best results!
Large Egg: To bind all of the ingredients together.
Boxed Yellow Butter Cake: Butter cake mix is the best if you can find it, but yellow cake mix will also work!
How to Make Gooey Butter Cookies
Anyone can make these butter cookies, they’re so simple! Just mix, shape, and throw them in the oven. The hardest part? Waiting for them to bake! They smell absolutely divine.
Preheat Oven, Prepare Pans: Preheat the oven to 350 degrees Fahrenheit and line two baking sheets with parchment paper. Then set aside.
Butter and Cream Cheese Mixture: Add the cream cheese, ¼ cup of powdered sugar, and the butter to a large bowl and beat with a hand mixer or a stand mixer fitted with the paddle attachment until combined.
Mix in Remaining Ingredients: Scrape down the sides and bottom of the bow, then add the vanilla, egg, and cake mix. Beat until combined.
Shape: Use a medium cookie scoop, about 2 tablespoons, to scoop the dough. Roll the scooped dough into uniform balls and then roll them in the remaining ¼ cup of powdered sugar until coated.
Bake: Place the cookies on the prepared baking sheets, leaving 2 inches between them. Bake for 10-12 minutes, until the edges of the cookies just start to brown.
Cool and Serve: Let the butter cookies cool on the baking sheet for 2-3 minutes before transferring them to a cooling rack to finish cooling.
Tips and Tricks
These gooey butter cookies are super easy to make, but here are a few more ways to achieve perfection!
Use Room Temperature Ingredients: Let the ingredients come to room temperature before mixing up the dough. Set the cream cheese, butter, and egg on the counter for at least an hour before you begin baking. This will allow the ingredients to incorporate better, without leaving little chunks unincorporated in the dough.
Add More Sugar as Needed: If ¼ cup of powdered sugar isn’t enough to roll all the cookies, use additional sugar as needed.
Avoid Overbaking: Don’t overbake your butter cookies! Bake them until the edges and tops just barely begin browning. They will finish baking as they cool on the cookie sheet for a few minutes.
Butter Cake Mix: Yellow Butter Cake will give you the best flavor, but regular yellow cake mix will work quite well if that is what you have on hand or what you can find at the store.
Storing Leftovers
Store leftover cookies at room temperature in an airtight container for up to 7 days. As they sit for a few days, sometimes the cookies can harden a bit. If they start to get too hard, you can throw a slice of sandwich bread in the container to help soften the cookies up.
Preheat the oven to 350 degrees Fahrenheit and line two baking sheets with parchment paper. Set aside.
Add the cream cheese, ¼ cup of powdered sugar, and the butter to a large bowl and beat with a hand mixer or a stand mixer fitted with the paddle attachment until combined.
Scrape down the sides and bottom of the bow, then add the vanilla, egg, and cake mix. Beat until combined.
Use a medium cookie scoop, about 2 tablespoons, to scoop the dough. Roll the scooped dough into uniform balls and then roll them in the remaining ¼ cup of powdered sugar until coated.
Place the cookies on the prepared baking sheets, leaving 2 inches between them. Bake for 10-12 minutes, until the edges of the cookies just start to brown.
Let the cookies cool on the baking sheet for 2-3 minutes before transferring them to a cooling rack to finish cooling.
I’ve mentioned before about my love of Italian food. While our family eats a lot of different ethnic dishes, Italian was one of the first I experimented with. This homemade Italian seasoning mix is the perfect way to season everything from pasta sauces to soups to meatballs.
Italian food is a classic weeknight dinner in many American households with our spaghetti sauce and pizza. Years ago when our family was healing from different autoimmune issues we switched to a grain-free diet. I learned quickly that pasta and dairy didn’t go well with our new lifestyle so I had to get creative.
I started making recipes like:
Homemade Italian Seasoning
I found myself buying jar after jar of organic Italian seasoning and it was getting expensive. Plus, I had to buy a tiny spice jar every few weeks because we went through it so quickly.
I was already ordering teas and lotion ingredients in bulk, so I decided to start ordering Italian herbs in bulk as well. The dried herbs at the grocery store often aren’t the freshest and most flavorful. By ordering from herb stores with fresher ingredients food tastes so much better! If you grow your own fresh herbs, you could also dry them and use those.
I store this and all my homemade herbal blends in half-pint glass jars. The lids are marked for easy use and they stack in the cabinet for easy storage. Any glass airtight container will work here though.
Italian Seasoning Ingredients
Here’s what I get for my Italian seasoning:
You could also add some red pepper flakes if your family likes it spicy, but I prefer to tailor the spice to each recipe. Onion powder and summer savory are also popular additions that didn’t make it into my family recipe. And if you’re on an autoimmune diet this is a tasty blend to have on hand to spice up your dishes.
Want to make more of your own spice blends? You can find my recipes for taco seasoning and many more here.
Homemade Italian Seasoning Recipe
Homemade Italian seasoning with dried herbs like basil, marjoram, oregano, rosemary, thyme, and garlic is a cost effective alternative to store bought pre-mixed seasonings.
If your rosemary is whole, rather than cut, simply chop it in a food processor or grind it with a mortar and pestle.
Combine all of the herbs in a glass jar and shake well to mix. You can also mix them in a small bowl and then transfer them to your jar.
Nutrition Facts
Homemade Italian Seasoning Recipe
Amount Per Serving (1 tsp)
Calories 7 Calories from Fat 1
% Daily Value*
Fat 0.1g0%
Saturated Fat 0.1g1%
Polyunsaturated Fat 0.03g
Monounsaturated Fat 0.03g
Sodium 2mg0%
Potassium 51mg1%
Carbohydrates 2g1%
Fiber 1g4%
Sugar 0.1g0%
Protein 0.5g1%
Vitamin A 58IU1%
Vitamin C 1mg1%
Calcium 53mg5%
Iron 2mg11%
* Percent Daily Values are based on a 2000 calorie diet.
All spices called for in this recipe are dried for longer shelf life.
How to Use the Italian Seasoning Blend
I’m sure you already know how to use Italian seasoning, but here are some more tasty Italian recipes to try it with!
What’s your favorite Italian dish to cook at home? Leave a comment and let us know!
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