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Authentic Spaghetti Sauce Recipe (Fresh or Canned Tomatoes)

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Authentic Italian food is a big tradition in our family. Over the years I’ve come up with plenty of healthy twists on our favorite Italian dishes that fit our lifestyle. One of the most delicious recipes is this homemade spaghetti sauce that goes great on rice noodles, zucchini noodles, and of course homemade meatballs.

Why Homemade Pasta Sauce?

Years ago I became privy to my Nonna’s best spaghetti sauce recipe that uses pre-canned tomato sauce and diced tomatoes (that she probably canned herself). One year I attempted to mimic the recipe using fresh tomatoes since we had an abundance from our garden and came up with my own pasta sauce recipe. It’s great on homemade “spaghetti” and meatballs, especially with a little parmesan cheese.

I’m sharing my variations of both today:

How to Make Pasta Sauce from Fresh or Canned Tomatoes

If you’re working from fresh tomatoes, use the first recipe. If you’re using canned tomatoes, use the second. I cook this on the stovetop, but you could also simmer them down in a Crockpot or slow cooker if preferred.

While “Nonna’s Recipe” is still the gold standard of spaghetti sauce in our family, I’m not sure I’m allowed to share the secret recipe. Instead, I’m sharing my own variations. I know I can share one part of her secret, which is to throw a piece of a carrot into the sauce while it’s cooking. This absorbs the acidity of the tomatoes and creates a sweeter sauce. It also removes the need for a sweetener to cut down the acidity.

This spaghetti sauce is great for an easy weeknight dinner, especially if you can it for later. Plus we think it tastes a lot better than jarred sauce from the store.

 

spaghetti sauce

Homemade Spaghetti Sauce With Fresh Tomatoes

Authentic tomato marinara sauce from fresh tomatoes, basil, and garlic.

  • Grate half of the carrot.

  • Pour the olive oil into a large stockpot or Dutch oven over medium-high heat.

  • When hot, add the diced onions to the olive oil and saute for 5 minutes.

  • Add the minced garlic and grated carrot and saute for 2-3 minutes longer or until onions are translucent and tender.

  • Add the tomatoes, chopped basil leaves, oregano, thyme bay leaves, parsley, and sea salt.

  • Simmer on low heat for 2-3 hours or until cooked down and starting to darken.

  • Add carrot piece for the last 30 minutes to absorb acidity while the sauce thickens.

  • Remove the sprigs of fresh herbs, bay leaves, and piece of carrot.

  • Optional: Use an immersion blender to puree sauce until smooth (for a thicker sauce, skip this step).

  • Use fresh or store in the refrigerator up to 1 week, or can it according to your canner’s instructions for tomato products.

Nutrition Facts

Homemade Spaghetti Sauce With Fresh Tomatoes

Amount Per Serving (0.5 cup)

Calories 144
Calories from Fat 63

% Daily Value*

Fat 7g11%

Saturated Fat 1g6%

Polyunsaturated Fat 1g

Monounsaturated Fat 5g

Sodium 313mg14%

Potassium 778mg22%

Carbohydrates 19g6%

Fiber 5g21%

Sugar 12g13%

Protein 3g6%

Vitamin A 3722IU74%

Vitamin C 44mg53%

Calcium 53mg5%

Iron 1mg6%

* Percent Daily Values are based on a 2000 calorie diet.

To peel fresh tomatoes (or peaches) cut a small “x” on the top and drop into boiling water for 10 seconds and then drop into an ice bath. The skin will easily peel off.

spaghetti sauce

30 Minute Homemade Spaghetti Sauce With Canned Tomatoes

If a two-hour simmer time isn’t your thing, this recipe tastes almost as good and cooks in much less time. This is my go-to on a busy night when I have 30 minutes to turn a pound of ground beef into dinner.

  • 2 medium onions (chopped)
  • 8 cloves fresh garlic (minced)
  • ¼ cup olive oil
  • 56 ounces crushed tomatoes (or whole or stewed tomatoes)
  • 6 ounces tomato paste
  • ½ tsp dried oregano
  • 1 TBSP dried basil leaves or 1/4 cup fresh, finely chopped
  • 2 bay leaves optional
  • ½ tsp dried thyme optional
  • salt (to taste)
  • black pepper (to taste)
  • Heat the olive oil in a medium-sized or large pot over medium heat. Add onions and saute until soft, about 5 minutes

  • Add minced garlic and saute for another minute.

  • Then, add tomatoes, tomato paste, oregano, basil, bay leaves, thyme, salt, and pepper.

  • Bring to a boil and immediately reduce to a simmer.

  • Simmer for 10-15 minutes to let flavors meld. (Can simmer longer if desired for a thicker sauce with a deeper flavor).

  • Serve over spaghetti noodles or pasta of choice.

Nutrition Facts

30 Minute Homemade Spaghetti Sauce With Canned Tomatoes

Amount Per Serving (0.5 cup)

Calories 158
Calories from Fat 63

% Daily Value*

Fat 7g11%

Saturated Fat 1g6%

Polyunsaturated Fat 1g

Monounsaturated Fat 5g

Sodium 577mg25%

Potassium 865mg25%

Carbohydrates 22g7%

Fiber 5g21%

Sugar 13g14%

Protein 5g10%

Vitamin A 761IU15%

Vitamin C 26mg32%

Calcium 102mg10%

Iron 4mg22%

* Percent Daily Values are based on a 2000 calorie diet.

  • For a thinner sauce that works better for pizza, chicken parmesan, etc, use an immersion blender to blend until smooth.
  • This recipe yields about 4 cups of sauce.

How to Use Homemade Pasta Sauce

You probably already have a recipe in mind since you’re reading this post, but this is endlessly versatile and great in many recipes. The fresh tomato recipe variation is great for tomato season, and I often can any extras to use in the winter.

It works great with Italian sausage, beef, and even ground turkey. I’ll often serve it with zucchini noodles and chopped up bell peppers for extra veggies.

I use this sauce in:

How to Can Your Own Pasta Sauce

You can easily make a large batch of either of these sauces and can it for future use. I often do this when we have an abundance of tomatoes from the garden. There’s really no reason to can the recipe made from canned tomatoes since it’s quick to whip up and there’s no need for the extra step.

Canning Instructions for Homemade Tomato Sauce

I follow these instructions for canning my homemade tomato sauce. There’s some debate if it’s ok to water bath can tomato products or not. The general consensus seems to be that tomatoes are iffy for water bath canning because the pH is sometimes not quite acidic enough. One solution is to add 1 teaspoon of lemon juice per pint for canning or check the pH to make sure it is 4.4 or below.

I prefer to just pressure can according to my pressure canner instructions. The pressure is enough to kill any botulism spores and is considered safe for tomatoes.

How to Freeze Homemade Tomato Sauce

If canning isn’t your thing, you can also freeze this homemade sauce. I like to freeze in quart-size glass mason jars (here’s how) or metal containers, to avoid the plastic in freezer bags. You can also freeze this sauce in any airtight container once it has cooled.

What are your favorite ways to use spaghetti sauce? Leave a comment and let me know!

 

An authentic homemade Italian pasta sauce recipe using fresh tomatoes and herbs.

 

 



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Butantan-Dengue Vaccine Shows Promising Results in Prevention

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The largest burden of dengue disease occurs in Southeast Asia and Central and South America. The New England Journal of Medicine published the results of a phase 3, double-blind trial conducted in Brazil, which evaluated the efficacy of the Butantan-Dengue Vaccine (Butantan-DV). This vaccine is a tetravalent, live attenuated candidate administered in a single dose and is under investigation for the prevention of dengue disease. The trial demonstrated that a single dose of Butantan-DV effectively prevented symptomatic DENV-1 and DENV-2 infections, regardless of the participants’ initial dengue serostatus, over a follow-up period of 2 years.

During 3 years of enrollment, 16,235 participants were divided to receive either the investigational vaccine (10,259 participants) or a placebo (5,976 participants). The vaccine demonstrated an overall efficacy of 79.6% (95% confidence interval (CI), 70.0 to 86.3) over two years. Specifically, efficacy was 73.6% (95% CI, 57.6 to 83.7) among those without prior dengue exposure and 89.2% (95% CI, 77.6 to 95.6) among participants with previous exposure to the virus. In terms of age groups, vaccine efficacy was observed at 80.1% (95% CI, 66.0 to 88.4) in participants aged 2 to 6 years, 77.8% (95% CI, 55.6 to 89.6) in those aged 7 to 17 years, and 90.0% (95% CI, 68.2 to 97.5) in the 18 to 59-year-old cohort.

“Approximately half the participants in our trial did not have evidence of previous dengue exposure at baseline, which enabled robust assessments of vaccine efficacy and safety in this population,” wrote the investigators. “In the current trial, we enrolled a substantial percentage of participants without previous dengue exposure whom we plan to follow up for a projected 5 years in a country where dengue is endemic, thereby allowing a careful assessment of vaccine efficacy and safety in this population.”

The vaccine showed an efficacy of 89.5% (95% CI, 78.7 to 95.0) against DENV-1 and 69.6% (95% CI, 50.8 to 81.5) against DENV-2. There were no cases of DENV-3 and DENV-4 detected during the follow-up. Within 21 days following injection, solicited systemic adverse events related to either the vaccine or placebo were more frequent in the vaccine group than in the placebo group, affecting 58.3% of vaccine recipients compared to 45.6% of those given the placebo.

Main Takeaways

  1. The Butantan-DV demonstrated significant efficacy in preventing symptomatic dengue caused by DENV-1 and DENV-2 serotypes, with an overall efficacy rate of 79.6% over 2 years.
  2. The trial also assessed the safety of the vaccine, noting a higher incidence of solicited systemic adverse events in the vaccine group compared to the placebo within the first 21 days post-vaccination.
  3. Efficacy varied by serostatus and age, with particularly high efficacy (89.2%) among those with prior dengue exposure and strong protection in all age groups, including a 73% efficacy in children aged 2 to 6 years without previous exposure.

The trial aimed to assess the overall efficacy of the vaccine in preventing symptomatic, virologically confirmed dengue of any serotype that occurred more than 28 days post-vaccination without consideration of baseline serostatus. Additionally, it sought to evaluate safety up to day 21 post-vaccination. Vaccine efficacy was determined based on a 2-year follow-up period for each participant, while safety was evaluated through the reporting of solicited adverse events related to the vaccine within 21 days following the injection.

“The effect of dengue serostatus at baseline on vaccine efficacy and safety is particularly important for young children, who are less likely to have had previous dengue exposure at the time of vaccination,” wrote the investigators. “Approximately one-third of the participants were 2 to 6 years of age, 81% of whom had not had previous dengue exposure, which makes this age group an ideal target for vaccination to protect against first infection. After 2 years of follow-up, vaccine efficacy among children 2 to 6 years of age without previous dengue exposure was 73%, a finding which is like that in the older age groups.”

Limitations include the absence of DENV-3 and DENV-4 cases during the follow-up. The trial demonstrated protection against DENV-1 and DENV-2, which are often linked to more severe disease outcomes. The Zika outbreak might have influenced the lower dengue incidence observed from 2016 to 2018. Additionally, the low incidence of severe dengue cases limited the ability to conduct meaningful analyses and raised concerns about unblinding in this study. The reliance on serologic tests, which detect cross-reactive antibodies complicates the understanding of type-specific immunity’s effect on vaccine efficacy.

“The single-dose schedule of Butantan-DV was advanced to the current phase 3 trial,” investigators wrote. “A single dose of Butantan-DV offered protection against symptomatic, virologically confirmed dengue over the follow-up period. In previous trials, a second dose of Butantan-DV or TV003 given at 6 months or 12 months did not induce vaccine viremia or substantially boost antibody responses.”

This study demonstrated that a single dose of the investigational vaccine is safe and effective in preventing symptomatic, virologically confirmed dengue from DENV-1 and DENV-2, regardless of prior dengue exposure, over a 2-year follow-up period. The findings endorse the ongoing development of Butantan-DV as a preventive measure against dengue in both adults and children. Ongoing follow-up extending to 5 years will seek to provide more definitive long-term safety and efficacy data.

Reference

Kallás E, Cintra M, Moreira J, Patiño E, Braga P, et al. Live, attenuated, tetravalent butantan-dengue vaccine in children and adults. The New England Journal of Medicine. Published February 1, 2024. Access February 7, 2024. DOI: 10.1056/NEJMoa2301790



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Martha Washington Candy | The Recipe Critic

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This website may contain affiliate links and advertising so that we can provide recipes to you. Read my disclosure policy.

Martha Washington Candy is an easy no-bake treat filled with cherries, coconut and pecans, and then coated in chocolate. Perfect for Christmas and Valentine’s Day!

Chocolate-covered anything makes for such an irresistible sweet treat! We love classic Chocolate Covered Strawberries, creamy Chocolate Covered Banana Bites and amazing Chocolate Covered Oreos. They’re all so easy and great for any occasion!

What is Martha Washington Candy?

Martha Washington Candy is one of the those old-fashioned recipes that gets passed down from generation to generation! They are nostalgic and heart-warming, and my favorite kind of recipe to make for my family and friends. It’s unclear how these little bites of heaven originated, but most conclude that they were invented by a chain of candy stores. These stores were popular from the 1890s until the depression in the 1920s.

They are always filled with a creamy coconut center with some type of nuts, and then covered in chocolate. Often recipes include maraschino cherries, which, in my opinion, gives them an extra special taste. Plus, the pop of red color in the center makes them perfect for homemade gift-giving during the holiday season, and for Valentine’s Day treats!

Ingredients Needed

Making this Martha Washington Candy recipe with my kids is a cherished family tradition. Luckily, the ingredients are simple pantry staples that you may already have on-hand. Here’s everything you’ll need, and you’ll find the exact measurements in the recipe card.

  • Maraschino Cherries: These are preserved, sweetened cherries that are the signature ingredient for this Martha Washington Candy recipe. 
  • Unsalted Butter: Holds the filling together while adding rich, buttery flavor.
  • Sweetened Condensed Milk: Makes every bite of these confections super creamy, rich and sweet!
  • Shredded Sweetened Coconut: Shredded coconut pairs wonderfully with the fruity cherries, crunchy nuts and chocolate.
  • Powdered Sugar: To sweeten these bites of delight!
  • Pecans: Toasted pecans add the perfect nutty crunch that is a great contrast to the creamy center.
  • Vanilla Extract: For a subtle sweet warmth.
  • Dark Chocolate: You can use dark coating chocolate or candy melts for the outside chocolate coating of the candies.

How to Make Martha Washington Candy

These candies are so easy to make! No need to turn on the oven, and you don’t even need a mixer! Here’s how simply they come together:

  • Prep: Prepare the maraschino cherries by roughly chopping them into small pieces and then pressing as much juice out of them by squeezing them in cheesecloth or paper towels. Set aside.
  • Make the Filling: In a large bowl, melt the butter. Add the sweetened condensed milk, coconut, powdered sugar, pecans, vanilla, and the prepared maraschino cherries. Mix together until combined.
  • Chill & Roll Into Balls: Cover the bowl and chill in the refrigerator for at least 30 minutes. Once chilled, use a medium cookie scoop or a spoon to scoop 3-tablespoon-sized portions into your hand. Roll with your hands to make a uniform ball. Don’t worry if the coconut sticks out here and there.
  • Chill: Place the balls on a parchment-lined baking sheet and chill in the fridge while you prepare the coating chocolate.
  • Make the Chocolate Coating: Add the coating chocolate to a small bowl and heat in the microwave for about 1 minute, heating in 20-second intervals. Stir well between each intervals until all the chocolate is melted.
  • Dip Into Chocolate & Chill: Use a fork to dip the balls in the chocolate until the are fully coated, tapping off the excess on the side of the bowl. Place the coated balls back on the parchment-lined baking sheet. Chill until the chocolate has fully hardened.

Tips and Variations

Here are a few tips to give you success in making Martha Washington Candies! Even though they look super fancy, they’re actually so simple to make! You can also change them up and make them your own!

  • Make Them Plain: If you do not care for maraschino cherries or pecans, they may be omitted from the recipe. 
  • Cherry Prep Tip: Try to get as much liquid out of the cherries as possible. Too much moisture from them will make the filling too soft and it won’t set up the way it’s supposed to. Measure the 10 ounces of cherries after they have been removed from the jar and chopped, but not before all the liquid has been squeezed out of them. 
  • Chocolate Chips: You may use regular chocolate chips to coat the candy instead of candy melts or coating chocolate. Add 1 teaspoon of coconut oil to each cup of chocolate chips that you use to give it a softer bite. 
  • Best Chocolate: For the best coating chocolate to use in this recipe, look for Ghirardelli dark chocolate coating wafers. They taste phenomenal with the coconut filling!
  • Toasting Nuts: To toast your pecans, roast them in a single layer at 350 degrees Fahrenheit for about 7 minutes, or until they darken slightly in color and become very fragrant. Let them cool completely before chopping them and adding them to the filling. 

Storing Leftovers

Once your Martha Washington Candy has cooled and is set, you’re ready to enjoy it or save it for later. This is a great dessert recipe to make ahead of time because it keeps well for a long time. I like to wrap it up and share it with friends and neighbors during the holidays!

  • At Room Temperature: This candy may be stored at room temperature for up to 2 weeks.
  • In the Refrigerator: For longer storage, place it in an airtight container in the fridge for up to 3 weeks.
  • Freezer: It’s even freezer-friendly! Store it in a freezer-safe bag or container for up to 3 months. If frozen, allow them to thaw for 2 hours at room temperature. 

More Candy Recipes

Once you have made these delectable candies, you are going to want even more candy recipes! Whether it’s for a holiday celebration, a party or just for snacking on at home, these are some of our favorites that we love to make and enjoy!

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  • Prepare the maraschino cherries by roughly chopping them into small pieces and then pressing as much juice out of them by squeezing them in cheesecloth or paper towels. Set aside.

  • In a large bowl, melt the butter. Add the sweetened condensed milk, coconut, powdered sugar, pecans, vanilla, and the prepared maraschino cherries. Mix together until combined.

  • Cover the bowl and chill in the refrigerator for at least 30 minutes. Once chilled, use a medium cookie scoop or a spoon to scoop 3-tablespoon-sized portions into your hand. Roll with your hands to make a uniform ball. Don’t worry if the coconut sticks out here and there.

  • Place the balls on a parchment-lined baking sheet and chill in the fridge while you prepare the coating chocolate.

  • Add the coating chocolate to a small bowl and heat in the microwave for about 1 minute, heating in 20-second intervals. Stir well between each intervals until all the chocolate is melted.

  • Use a fork to dip the balls in the chocolate until the are fully coated, tapping off the excess on the side of the bowl. Place the coated balls back on the parchment-lined baking sheet. Chill until the chocolate has fully hardened.

Calories: 173kcalCarbohydrates: 19gProtein: 1gFat: 11gSaturated Fat: 7gPolyunsaturated Fat: 1gMonounsaturated Fat: 3gTrans Fat: 0.1gCholesterol: 10mgSodium: 12mgPotassium: 82mgFiber: 2gSugar: 17gVitamin A: 117IUVitamin C: 0.3mgCalcium: 28mgIron: 0.4mg

Nutrition information is automatically calculated, so should only be used as an approximation.





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10 covered Marketplace health benefits

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Published on June 29, 2023

All private health insurance plans offered in the Health Insurance Marketplace® must cover the same . Care in these 10 categories of services is covered by all Marketplace plans.

10 covered benefits:

  • Ambulatory patient services (outpatient care you get without being admitted to a hospital)
  • Emergency services
  • Hospitalization (like surgery and overnight stays)
  • Pregnancy and newborn care (both before and after birth)
  • Mental health and substance use disorder services, including behavioral health treatment, counseling, and psychotherapy
  • Prescription drugs
  • Rehabilitative and habilitative services and devices
  • Laboratory services
  • Preventive and wellness services and chronic disease management
  • Pediatric services, including oral and vision care (this doesn’t include adult dental or vision coverage)



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The Emotional Side of Treatment I Wasn’t Prepared For

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By Natalie Brown, as told to Kendall Morgan

When I was diagnosed with stage IV lung cancer at age 33, I had to make a lot of tough decisions quickly, including whether to freeze my eggs before treatment started or not be able to have kids. We decided to go ahead with treatment immediately. In the beginning of treatment, I felt awful. I was exhausted, and there was little I could do. It took time to come to terms with the diagnosis. How I feel mentally still changes day to day.

Overall, the emotional impact and experience hasn’t been what I expected in the beginning. I didn’t expect treatment to go the way that it is going. It’s going surprisingly well for stage IV, so let’s start there. But I say emotionally, every treatment is completely different. Sometimes, I can go through treatment and it’s like, “Hey, I have chemo.” Sometimes, it’s like, “Oh my gosh, I can’t believe I have lung cancer. I can’t believe I’m having to put poison in my body.”

I have to alter my life around treatment. I’ll do as much as I can before the medicine kicks in. I still work and it is very difficult to try and work and be on treatment at the same time. If I have treatment on a Monday, I’ll do all I can because by Wednesday or Thursday, I might not feel like walking up the steps.

Emotionally, it’s all over the place. It’s like a rollercoaster. Sometimes you are up and sometimes you are down. It’s a complex combination of emotions with treatment every 3 weeks. I know I’ll be down for a week, so I’ll hurry and stress. I’ll make sure all the clothes are washed. My husband helps, of course, but I want a clean house when I’m in treatment. I rush around, cooking, cleaning, or ordering food because I won’t feel like cooking. It’s a lot of anxiety to make sure things are perfect before treatment. If I don’t get it all done, then I’ll try and do it in the week of treatment and it makes me more fatigued. That’s when it gets frustrating.

Sometimes I just shut down. Two treatments ago, I cried and cried because I was so fatigued to the point where I couldn’t believe I was having to deal with this. I cried the whole week. I didn’t want to talk to anyone or get on social media. I went into a funk. It happens periodically. You’re just so tired. The fatigue weighs on you the most, no matter how much you sleep.

To help with the emotions, I found support through a mentoring program and online. I started seeing a therapist for the first time in my life. I thought at first I could handle this without professional help, but I couldn’t. Seeing a therapist has helped.

 

 

A lot of friends got me books. I tried reading them, but I’d read 20 pages and I just couldn’t do it. I started listening to podcasts and that’s better for me. Those seem to help. I listen to a lot of music, especially during treatment weeks. Slow, soft music seems to help a little bit. I take bubble baths, and I never did that before. Relaxing in a tub with candles. That helps a lot.

You have to give it time. I was not immediately able to talk about this the way I am now. I had to take the time to digest the fact of cancer and then I could share my story. Awareness is extremely important, especially in lung cancer.

Through it all, I find reasons to celebrate. I’m turning 35 this year. It’s another birthday, but it’s also another year celebrating that I’m still here. I celebrate everybody’s birthday. I celebrate scans. I had one a couple of weeks ago that was really good. I make sure to celebrate any little thing. Before cancer, I didn’t do that. I celebrated birthdays but not to the extreme. Now, that’s super important to me. It doesn’t have to be anything big. Any small situation, I make it celebratory. This experience has turned me into a more positive human. It sounds crazy. You’d think the opposite. But I’m so much more positive in life than before.



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Inhaled “Immunoantimicrobial” Investigated for COPD

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Experimental, inhaled nanoparticles that incorporate antimicrobial peptides (AMPs) and encapsulate an antibiotic were demonstrated to penetrate mucus and biofilm barriers to quell infection and related inflammation, in a mouse model of exacerbated chronic obstructive pulmonary disease (COPD).

Junliang Zhu, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, China and colleagues sought to deliver antimicrobials directly to the lung via nebulization to reduce systemic exposure and diminish potential side effects.The dosage form would have to overcome multiple pathophysiologic barriers, however, including hypersecretion of mucus in the upper airway and bronchi characteristic of COPD, and the biofilms formed by bacteria colonizing the lungs.

“Effective mucus and biofilm penetration are critically imperative for inhaled antimicrobials,” Zhu and colleagues declared.

Their approach exploited particular obstructive mechanisms that they encountered within those barriers:the viscous mucus layer lining above the bronchial epithelium trapped antimicrobials through electrostatic attraction with mucin; and the extracellular polymeric substance (EPS) matrix of the biofilms captured positively charged antimicrobial compounds.

They posited that a negatively charged nanoparticle shell, which they constructed from porous silica, would penetrate mucus and biofilm through electrostatic repulsion with glycoproteins and polysaccharides; the incorporated polypeptides would be “conditionally activated” inside the mildly acidic biofilm; and the encapsulated antibiotic (ceftazidime) would be released as the acidity changed the shell charge from negative to positive.

The chemical mechanism for activation of the polypeptides, Zhu and colleagues explain, is the acid-triggered removal of their carboxyl groups.This change transforms them from negatively charged, flexible random coil with low affinity for bacterial membranes, to a positively charged, rigid α-helix “with a potent capacity to disrupt bacterial membranes.”

The investigators reported that the penetration of the barriers and release of active agents was measurable in both in vitro and in vivo settings, as was the eradication of microbes.In addition to the antibacterial action of ceftazidime, the investigators found that the positively charged polypeptides effectively scavenged bacterial e- and g-DNA, to inhibit the infiltration and activation of immune cells, and mitigate the infection-associated inflammation.

“With these unique properties, the IMAMs (immunoantimicrobials) demonstrated potent therapeutic efficacy in mice with COPD exacerbations, effectively eradicating lung-colonizing bacteria and inhibiting TLR9 (toll-like receptor 9) activation to alleviate pulmonary inflammation,” Zhu and colleagues reported.

What You Need to Know

Study introduces a novel therapeutic approach utilizing experimental, inhaled nanoparticles incorporating antimicrobial peptides (AMPs) and encapsulating an antibiotic (ceftazidime) for the treatment of chronic obstructive pulmonary disease (COPD) exacerbations.

The nanoparticles are designed to overcome the barriers posed by mucus and biofilms in the lungs, which are characteristic of COPD.

The study demonstrates promising therapeutic efficacy in both in vitro and in vivo settings.

The investigators acknowledge that among the questions remaining after this animal model study is whether the nanoparticles are cleared from the lungs.

“The repeated nebulization of silica-based nanomaterials may raise concerns about pulmonary fibrosis, and thus, the long-term safety of IMAMs alongside the degradation profiles of silica nanomaterials should by systematically studied,” Zhu and colleagues indicated.

In addition, the investigators point out the challenge of developing complex manufacturing practices to manage batch-to-batch variance of the nanoparticle antimicrobial delivery systems.

“Nevertheless, our study clearly demonstrates that the vast therapeutic potential of IMAMs is poised to shift the paradigm in COPD management,” Zhu and colleagues claim.

Reference

1Zhu J, Li X, Zhou Y, et al. Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease. Sci Adv 2024; 10: eabd7904.https://www.science.org/doi/10.1126/sciadv.abd7904.Accessed Feb 7, 2024.



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Garlic Parmesan Pull-Apart Bread Recipe

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This website may contain affiliate links and advertising so that we can provide recipes to you. Read my disclosure policy.

This garlic parmesan pull-apart bread is soft, flavorful, and beyond easy to make! It’s filled with cheesy garlic flavor and is just the perfect size for dipping in all of your favorite sauces!

Name a better duo than garlic and parmesan. I’ll wait. It just goes so well with so many different types of dishes! If you love this flavor combo as much as I do, you’ll have to try out these garlic parmesan chicken wings, zucchini spears, or roasted potatoes next. They’re all so irresistible!

Picking up a piece of garlic parmesan pull-apart bread.

Garlic Parmesan Pull-Apart Rolls

This garlic parmesan pull-apart bread is one of my family’s all-time favorite sides. My kids are always requesting it! It’s soft, warm, cheesy, and has the best savory flavor. It tastes heavenly served up with some homemade marinara or alfredo sauce for dipping! However, the best part about this recipe is the fact that you only need a can of Grands biscuits and a couple other simple ingredients to whip it up. It really doesn’t get any easier than this!

Garlic parmesan pull-apart bread makes dinner a breeze. I love that all I have to do is mix all of the ingredients together and then throw them in the oven! These rolls are the perfect side. They’re great paired with anything from pizza to pasta or just served as an appetizer! My family loves having them around to munch on for game days. I know they’ll be just as much of a hit at your house! Because you just really can’t go wrong with warm bread smothered in butter, cheese, and garlic.

Don’t Worry!

This recipe is Picky Eater Approved!

Ingredients You’ll Need

Even though this garlic parmesan pull-apart bread uses Grands biscuits, it tastes homemade! I love that you only need a few simple ingredients to throw it together. It’s an inexpensive side that the whole family will go crazy over! Check out the recipe card below for exact measurements.

  • Grands Biscuits: I love working with Grands biscuits! They’re so versatile! I just used the regular kind here, not the flaky layers.
  • Butter: Adds flavor and helps your pull-apart bread turn out perfectly golden brown!
  • Garlic: I always like to go for fresh minced garlic with these rolls, but garlic powder will work too if you don’t have any on hand.
  • Parmesan Cheese: I use both shredded and grated in this recipe. The shredded parmesan melts and the grated gives it a cheesy texture! The flavor pairs perfectly with garlic, too!
  • Italian Seasoning: You can’t go wrong by adding some savory herbs! Use prepackaged Italian seasoning or make your own blend. You can find my full recipe here!
  • Garlic Salt: Just a little bit of garlic salt seasons this pull-apart bread perfectly!

How to Make Garlic Parmesan Pull-Apart Bread

It’s so easy, anyone can do it! All you have to do is combine all of the ingredients and then bake! You’re going to be so amazed when you pull golden brown, cheesy goodness out of the oven.

  1. Preheat Oven/ Prepare Pan: Preheat the oven to 350 degrees Fahrenheit. Spray the bundt pan with non-stick cooking spray and then set aside.
  2. Cut Biscuits/ Add Ingredients: Cut the Grands biscuits into quarters and add to a large bowl. Then add the garlic, Italian Seasoning, garlic salt, and both types of cheese to the bowl.
  3. Melt Better/ Toss to Combine: Melt the butter in the microwave then add to the biscuit mixture. Then toss to coat the biscuits and combine the ingredients.
  4. Bake and Enjoy: Bake for 20- 25 minutes until golden brown. Turn out onto a dish and enjoy it with marinara sauce on the side!
The biscuit dough being coated in a cheesy coating and added to a bundt pan.

A Reader’s Review

So addictive. I could not stop eating them. No changes to recipe, just make the way you did.

Holly

Garlic parmesan pull-apart bread served around a bowl of marinara.

Tasty Dipping Sauces

This garlic parmesan pull-apart bread is absolutely delicious on its own, but even better served with tasty dips! These are a few of my family’s favorite dips. We can’t have breadsticks in my house without them! Whether you want some classic marinara, something garlicky, or packed with cheesy flavor, there’s a dip for every craving! Make some of these homemade sauces for your next pizza or pasta night! Your family is going to love them.

Storing Leftovers

This delicious cheesy bread never lasts long at my house. In fact, I don’t think we’ve ever had leftovers! They’re always gone in a snap. If you’re lucky enough to have some leftover, here’s how to keep them tasting fresh and delicious for a few days!

  • At Room Temperature: You’ll want to keep this garlic parmesan pull-apart bread covered so it doesn’t dry out as quickly. Wrap in plastic wrap or store in an airtight container. It will stay good for 2 days.

Dipping a cheesy roll into the marinara sauce.

More Delicious Sides

Serving bread or breadsticks with dinner is always a good idea. Here are a few of my favorite recipes to up-level the usual dinner roll. Your guests are going to love them! They’re the perfect addition to any hearty meal.

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  • Preheat the oven to 350 degrees Fahrenheit. Spray the bundt pan with non-stick cooking spray and set aside.

  • Cut the Grands biscuits into quarters and add to a large bowl. Add the garlic, Italian seasoning, garlic salt, and both types of cheese to the bowl.

  • Melt the butter in the microwave then add to the biscuit mixture. Toss to coat the biscuits and combine the ingredients.

  • Bake for 20- 25 minutes until golden brown. Turn out onto a dish and enjoy it with marinara sauce on the side!

Originally posted October 21, 2022
Updated on February 10, 2024

Calories: 400kcalCarbohydrates: 38gProtein: 9gFat: 24gSaturated Fat: 9gPolyunsaturated Fat: 5gMonounsaturated Fat: 8gTrans Fat: 0.3gCholesterol: 30mgSodium: 1035mgPotassium: 193mgFiber: 1gSugar: 3gVitamin A: 341IUVitamin C: 0.2mgCalcium: 195mgIron: 3mg

Nutrition information is automatically calculated, so should only be used as an approximation.





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Moving can impact your health coverage options and savings

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Published on July 13, 2023

As you get ready to move, it’s important to know that your new address may impact your health coverage options and savings. Don’t forget to update your Marketplace application to get the best plan for your household, and the right amount of savings. 

Your next steps depend on where you move

When you move to a new state

  • You can’t keep the same plan from your old state. Let the Marketplace know if you move to a different state right away, so you don’t have a break in coverage or continue to pay for coverage that doesn’t apply in your new state.
  • To get coverage in your new state, start a new Marketplace application and enroll in a plan in your new state. How you apply depends on whether your new state uses HealthCare.gov or its own website.
  • Apply for Marketplace coverage in your new state.

If you move within the same state:



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The Best High Fiber Foods (and Why We Need Them)

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Improving fiber intake should be a top priority for many of us. But fiber doesn’t need to be a stir-in fiber supplement from the local drugstore. Many of the healthiest diets naturally include fiber – except the carnivore diet, of course. It’s just a matter of knowing which foods are high in fiber and when to include them. Here’s what you should know about high-fiber foods.

What is Dietary Fiber? 

Dietary fiber is the part of plant foods that passes through the digestive system, more or less intact. It’s a carbohydrate in fruits, vegetables, grains, nuts, seeds, and legumes. Unlike other carbs, fiber doesn’t easily break down into sugar molecules. So, it doesn’t provide calories or energy to the body. There are two main types of fiber: Soluble and Insoluble. 

Soluble fiber dissolves in water, forming a gel-like substance in the digestive tract. It’s known for helping to balance cholesterol and blood sugar levels. Examples of foods high in soluble fiber are oats, legumes, and root crops like carrots and sweet potatoes. You’ll also find it in certain fruits (apples, citrus, and strawberries) and cruciferous vegetables.

Insoluble fiber doesn’t dissolve in water. Instead, it adds bulk to the stool. That extra bulk can aid in regular bowel movements and may ease constipation. Examples of foods high in insoluble fiber are whole grains, leafy greens, cruciferous vegetables, and nuts. It’s also found in fruits, especially when eaten with the skins intact.

You’ll notice cruciferous vegetables have both soluble and insoluble fiber. One isn’t more important than the other. Including both types of fiber promotes a healthy digestive tract, ultimately affecting whole body health.

How Much Fiber Do We Really Need? 

The recommended daily fiber intake varies by age and gender. But it generally falls between 25 and 38 grams daily for adults. Of course, individual needs may vary based on activity level and overall health. The Academy of Nutrition and Dietetics recommends getting about 14 grams of fiber for every 1,000 calories a day.

Most Americans don’t get enough fiber in their diets. The modern emphasis on boxed and processed foods means we’re not getting enough whole foods. As a result, Americans are getting only about half the fiber they should.

If you don’t want to be part of that statistic, be sure to increase your fiber gradually. You don’t want to get up one day and decide to eat a high-fiber diet. Your digestive system may not be ready for that. It’s also important to get enough water (away from meals) to help avoid digestive discomfort.

Health Benefits of a High-Fiber Diet 

Better Digestive Health

Fiber can help prevent constipation by adding bulk to stools. The added bulk stimulates movement in the intestines, so it may promote regular bowel movements. 

Fiber can also act as a prebiotic, feeding beneficial gut bacteria. When the bacteria digest certain fibers, they produce what’s known as “postbiotics.” These short-chain fatty acids (SCFAs) feed cells lining the large intestine. As a result, gut inflammation can go down, and motility may improve. 

Improving motility in the gut may lower the risk of colon cancer. 

Potentially Avoid Colon Cancer

Improving motility in the gut may also help you avoid colon cancer. A large prospective study of over 75,000 participants looked at fiber and cancer risk. Higher fiber intake from foods was associated with a lower risk of colorectal cancer.

Improve Heart Health 

Increasing your fiber intake may protect against heart disease. Research shows as insoluble fiber increases, blood pressure and triglyceride levels decrease. A lower fiber intake is also associated with higher insulin levels. It’s no wonder high-fiber cereals are advertised as “heart-healthy.” Whether they truly are is the subject of another blog post.

Blood Sugar Balance

Soluble fiber can slow down sugar absorption, helping to stabilize blood glucose levels. This slower digestion prevents rapid spikes in blood sugar after meals. It does so by carefully regulating glucose release into the bloodstream. This is important for avoiding metabolic syndrome and diabetes.

High-fiber diets are also associated with improved insulin sensitivity. Insulin is a hormone responsible for regulating blood sugar levels. Increased insulin sensitivity means cells can more effectively use glucose from the bloodstream. That also helps to maintain stable blood sugar levels, reducing diabetes risk.

A Healthy Weight

High-fiber foods are often filling, which can help control appetite. It may do so by increasing a gut hormone called cholecystokinin (CCK). Researchers have found that fiber promotes the release of CCK into the bloodstream, reducing appetite. So, including plenty of fiber may help with weight loss if needed. 

A 2023 study looked at the success of a fiber-rich diet in 4,477 people over three years. Over 62% of them lost weight. On a high-fiber diet, the average weight loss was 7.23 pounds (3.28 kilograms). 

Which Foods Are Highest in Fiber?

Several foods are high in fiber, so there are lots of options. Incorporating these foods into your diet can certainly support digestive health. However, it may also improve overall health by supporting a healthy immune system.

Beans and Legumes

Beans, lentils, chickpeas, and green peas are excellent sources of fiber. For instance, black beans, kidney beans, navy beans, and pinto beans are particularly high in fiber. According to the USDA’s FoodData Central, here’s the fiber content of three common legumes:

  • Split peas have 16.3 grams per cup
  • Black beans have 15 grams per cup
  • Chickpeas have 12.5 grams per cup

There are many types of beans, and all are high in fiber. Lentils are available in green, black, and even red. Between beans, lentils, and peas, there are many options to work with.

Keep in mind that beans are also high in lectins which can damage the digestive system. When I was actively healing from autoimmune disease I avoided beans entirely. This article gives more details and explains some easy ways to reduce lectins and still get the benefits of beans.

Whole Grains and Grain-Like Seeds

Whole grains, if you eat them, are also excellent sources of fiber. Oats, brown rice, spelt, einkorn, and barley are high in fiber. Opting for whole grain varieties instead of refined grains increases your fiber intake. While brown rice is higher in fiber than white, our family only eats white rice (here’s why!). 

Grain-like seeds, like quinoa and millet, are also good sources of fiber.

Certain Vegetables

Just increasing your veggies can improve your fiber intake. Artichokes, broccoli, Brussels sprouts, carrots, kale, and other leafy greens are high-fiber vegetables. Peas (also a legume) and sweet potatoes both contribute decent amounts of fiber.

Berries and Other Fruits 

Raspberries, blackberries, strawberries, and blueberries are some of the best fruit sources. These fruits are also rich in antioxidants, which have additional health benefits. Pears, apples (with the skin), oranges, and bananas are also great sources of fiber.

Nuts and Seeds 

Almonds, chia seeds, flax seeds, and sunflower seeds are also fiber-rich. You can easily add them to cereals, yogurt, or on top of salads. Chia and flax seeds are also high in plant-based omega-3 fatty acids.

How to Get Enough Fiber if You Don’t Eat Grains? 

You don’t need to eat whole wheat berries daily to get your fiber in. If you’re following a grain-free or Paleo diet, there are still plenty of ways to get fiber outside whole grains. 

  • Non-Starchy Vegetables: Broccoli, kale, Brussels sprouts, bell peppers, asparagus, and cauliflower are fiber-rich. They also align with Paleo diet principles, and supply needed vitamin C. 
  • Root Vegetables: While some people may limit root vegetables due to carbs, sweet potatoes and carrots are good sources of fiber.
  • Fruits: Berries tend to be lower in sugar and higher in fiber compared to prunes and other fruits. Avocados are also a good source of fiber, potassium, and healthy fats.
  • Nuts and Seeds: Almonds, walnuts, flaxseeds, chia seeds, and pumpkin seeds are “Paleo.” They’re also good sources of fiber and healthy fats. 
  • Coconut: Coconut products, including coconut meat and coconut flour, are good sources of dietary fiber in Paleo recipes.

Who Should Avoid High-Fiber Foods?

While fiber is generally beneficial, certain people may need to limit high-fiber foods — at least for a while. Here’s who should consider limiting their intake of high-fiber foods:

Those with Active Disease Flares

Fiber can aggravate some digestive conditions like Crohn’s disease, ulcerative colitis, and diverticulitis. It may be fine during remission but not during flares. In such cases, high-fiber foods may need to be temporarily limited as directed by a healthcare provider. 

Those with Chronic IBS or SIBO

Those with irritable bowel syndrome (IBS) or small intestine bacterial overgrowth (SIBO) may not do well with more fiber. They may experience bloating, cramping, or digestive distress from adding high-fiber foods. Adjusting the types or amounts of fiber may help. For example, following a low-FODMAP diet may reduce symptoms.

FODMAP stands for Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols. It refers to certain carbohydrates that may worsen symptoms in those with these gut disorders. Read more about a  Low FODMAP Diet.

Those Recovering From Surgery

Doctors may recommend a low-fiber diet following certain types of surgeries or medical procedures. Gastrointestinal surgeries are a good example. When fully recovered, it may be fine to add back higher fiber foods. Check with your doctor to know for sure.

How to Include More Fiber in Your Diet

To increase your fiber intake, focus on eating whole foods. You can also choose to use recipes with high-fiber ingredients. Here are some easy ways to get more fiber in your diet:

Soups and Stews 

Add beans, lentils, chickpeas, and peas to soups and stews. Or, just focus on recipes that already include legumes. Here are a few ideas!

Legumes are a reliable way to increase your fiber intake. You can always add a can or two to a vegetable-based soup to increase the fiber count.

Eat Raw Vegetables with Dip 

For an easy lunch or healthy snacking, bring out a variety of raw vegetables. Then, pair them with fiber-rich hummus or guacamole. Try your crudites with these:

When pairing raw vegetables with fiber-rich dip, you’re doubling your efforts! 

Enjoy Nuts & Seeds as Snacks 

Snack on soaked or sprouted nuts and seeds. Almonds, walnuts, pecans, sunflower seeds, and pumpkin seeds are high in fiber and delicious. Toasted and included in a trail mix, they make a satisfying snack. Chia seeds are easy to include as a “pudding.” Try these! 

Nuts and seeds also show up as “flours” in grain-free pancakes and baking.

Embrace Grain-Free Flour Substitutes

Grain-free baking automatically uses high-fiber ingredients like nut flours, seed flours, and coconut flour. Here are some ideas to get you started: 

When you get away from white flour and refined pasta, increasing fiber is almost a given. Enjoy your fruits and vegetables in their whole, unprocessed form, and you’ll be surprised how easy (and delicious) it is to get your high-fiber foods in.

Do you try to eat a high-fiber diet? How do you purposely include more fiber each day? Share with us below!



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Positive Impact of Antiviral Therapy in Multiple Sclerosis

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Øivind Torkildsen, MD, PhD

This article originally appeared on our sister site, NeurologyLive.

A recently published case report of a patient with highly active multiple sclerosis (MS) who was also HIV positive showed that treatment with antiretrovirals (ART) containing tenofovir resulted in suppression of MS disease activity. Overall, these results suggest that the use of a potent inhibitor of Epstein-Barr virus (EBV) replication like tenofovir may be a potentially beneficial treatment option for MS.

The case study began in 2020, when investigators published a description of a 34-year-old woman with relapsing-remitting MS who was treated with a combination of ARTs containing tenofovir. At the time of her diagnosis in 2015, she began treatment with fingolimod (Gilenya; Novartis). Two years later, she was infected with HIV, where she began treatment with an integrase strand transfer inhibitor (INSTI)-based single-tablet regimen with 3 active agents consisting of a combination of elvitegravir, cobicistat, emtricitabine, and tenofovir alanfenamide (TAF).

After 2 years of stable disease activity while on fingolimod, the therapy was discontinued. In 2019, she switched from TAF to tenofovir disoproxil fumarate (TDF), which is known to have less potency against EBV replication. After the switch, she had 1 gadolinium-enhancing lesion on MRI, but no new clinical relapses. In addition, she reported that 2 of her MS-related symptoms, pain and fatigue, decreased, and her neuropathic pain was completely resolved.

“Tenofovir has excellent safety and tolerability profile and is also used as a pre-exposure prophylaxis (PrEP) in high-risk individuals to prevent HIV infection, making it a particularly strong candidate as a drug for primary prevention of virally acquired diseases,” lead author Øivind Torkildsen, MD, PhD, professor in the Department of Clinical Medicine at the University of Bergen, and colleagues, wrote. “Since EBV mainly resides in the latent phase in infected individuals, the observations on the use of TAF in patients with MS could help answer the question of whether lytic reactivation is necessary for disease activity in MS.”

In the years following the initial publication in 2020, the patient demonstrated no new relapses, Expanded Disability Status Scale progression, or MRI lesions while on a combination of raltegravir, emtricitabine, and TDF. In 2022, she switched to a one-tablet dosing regimen consisting of dolutegravir and rilpivirin, a non-nucleoside-reverse transcription inhibitor with no known effect on EBV-replication, which subsequently worsened her condition 5 months later.

Around that time, the patient began to show new signs of disease activity, including new gadolinium-enhancing lesions. Notably, she was hospitalized in October 2022 with an MRI-verified relapse and was subsequently treated with steroids. Months later, in June 2023, an MRI revealed new MS lesions, leading to the initiation of MS treatment with rituximab in June 2023.

“Since TAF and TDF mainly prevent the lytic reactivation of EBV, this could indicate that lytic reactivation is the primary driver of the disease process in MS. Several alternative explanations could also account for this potential effect. First, it is possible that the combined effect of CD4+ T cell repertoire depletion followed by sustained TAF-mediated suppression of the EBV-infected B cell compartment delayed priming and re-emergence of potentially pathogenic EBV-specific or autoreactive CD4+ T cells.”

“We therefore cannot know if the remission was primary due to the effect of TAF on EBV lytic replication, and not due to HIV-mediated depletion of the CD4+ T cell compartment itself,” the study authors added. “Secondly, an alternative hypothesis could be that TAF works primarily by inhibiting human endogenous retroviruses (HERV) which have been previously linked to MS disease pathogenesis.”

Currently there is 1 study on TDF (NCT05957913) and 1 study on TAF (EUCT number: 2023–503,814–62–00) that are being performed in patients with MS, where the main goal is to determine the effect on EBV shedding. The first of these two, a phase 2b trial of 50 participants with EBV, is expected to conclude by the end of 2024. This study assesses tenofovir/emtricitabine (Truvada) in standard doses, with the primary outcome of change in EBV viral load.

Reference
Torkildsen O, Myhr KM, Brugger-Synnes P, Bjornevik K. Antiviral therapy with tenofovir in MS. Mult Scler & Relat Disor. 2024;83:105436. doi:10.1016/j.msard.2024.105436



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