fbpx

Similar Efficacy of Ceftaroline and Vancomycin in Treating Complicated Skin and Soft Tissue Infections


Women scratching at her skin infection on her hand.

Image Credits: Unsplash

Complicated skin and soft tissue infections (cSSTIs), especially those caused by resistant pathogens like MRSA, pose a significant challenge in clinical management. The study findings suggest that ceftaroline and vancomycin demonstrate similar clinical cure rates for cSSTIs, despite potential differences in disease severity. While vancomycin led to shorter median hospital stays (3.9 days vs. 9 days for ceftaroline), no significant differences were observed in 30-day readmission rates, recurrence, time to oral antibiotic switch, or nephrotoxicity between the two treatment groups.

Despite numerically higher disease severity scores in the ceftaroline group, clinical cure rates remained comparable, with 88.7% for ceftaroline and 90.6% for vancomycin. Analysis of baseline characteristics revealed similarities between the two treatment groups, including median ages, body mass indexes (BMI), Acute Physiology and Chronic Health Evaluation (APACHE) scores, and Sequential Organ Failure Assessment (SOFA) scores.

The study conducted an interim analysis involving 106 individuals. The cohort consisted of adults diagnosed with cSSTIs who received at least 48 hours of either ceftaroline or vancomycin treatment and were discharged alive. Patients requiring prolonged antibiotic courses, combination therapy, pregnancy, or those incarcerated were excluded from the analysis.

In conclusion, further investigation into the full sample is warranted to comprehensively assess the efficacy and safety of both treatment modalities in managing cSSTIs caused by resistant pathogens like MRSA. This study holds promise for clinicians seeking optimized therapeutic strategies for challenging cSSTI cases.

Reference
Althubyani A, Beriashvili E, Wolowich W, et. al. Ceftaroline versus Vancomycin for the Treatment of Complicated Skin and Soft Tissue Infections (cSSTIs): A Retrospective Cohort Study. Abstract #53 OR presented MAD-ID The Antimicrobial Stewardship Meeting. May 8-11 Orlando, Florida.



Source link

Daily Dose of Insights

Get a daily infusion of knowledge with our latest blog updates.

We don’t spam! Read our privacy policy for more info.

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related articles

Experts highlight common waterborne illnesses, preventive tips for summer

Experts emphasize prevalent waterborne illnesses and offer preventive advice for the summer season.This article originally appeared on our sister...

Cowboy Queso Recipe | The Recipe Critic

This website may contain affiliate links and advertising so that we can provide recipes to you. Read...

My Food Rules To Help a Picky Eater

Over the years, I’ve gotten a lot of questions about how I get my kids to eat...

Addressing Suboptimal Treatment Response in HIV

A panel of experts on HIV discuss decision-making practices for patients who have suboptimal response to their...