fbpx
Home Blog Page 109

Can You Really Lose Weight With Two Workouts a Week?


March 6, 2024 – It turns out there may be something to the “weekend warrior” mentality after all. 

A recent study suggested that concentrating all your exercise into just 1 or 2 days could work as well for fat loss as spreading it throughout the week. 

The research builds on growing evidence that the weekend warrior exercise pattern can aid your health. A 2023 study of nearly 90,000 people found that weekend warriors were less likely to have a heart attack, stroke, or heart failure than inactive people. Another study of nearly 351,000 adults found no difference in risk of early death between weekend warriors and those who exercised three or more times a week. 

The new study was the first to examine the weekend warrior pattern and body fat, which was measured using dual-energy X-ray absorptiometry (DXA scan). 

“In [our] fast-paced society, we are interested in exploring alternatives to stay fit for individuals who cannot meet the recommended frequency,” said study author Lihua Zhang, MD, PhD, a health care scientist at Fuwai Hospital’s National Center for Cardiovascular Diseases in Beijing.

Using the National Health and Nutrition Examination Survey (NHANES), Zhang and colleagues analyzed data from 9,600 people. About 4,000 reported exercising for at least 150 minutes a week – the minimum amount of exercise recommended for adults. Most spread it out over 3 or more days, but 772 people, the weekend warriors, crammed it all into just 1 or 2 days.

Both groups – the weekend warriors and the more frequent movers – had less belly fat, a smaller waist, a lower body mass index, and less body fat than people who did not exercise regularly. And both groups were roughly the same on those measures, despite differences in exercise frequency. 

The results held regardless of diet. “No matter if someone had a healthy diet or not, the weekend warrior still was associated with lower adiposity,” or body fat, said Zhang.

Exercise and Weight Loss

That may be surprising, given that most research indicates that exercise alone plays a relatively small role in weight loss. (Though evidence does suggest that exercise may be important for maintaining body weight.) In studies that show weight loss resulting from exercise, the activity amount is usually substantial and the intensity high. 

In general, public health guidelines advise at least 300 minutes of moderate to vigorous exercise a week for weight loss. Even then, results may not be dramatic: A 2022 analysis of 25 trials concluded that at least 3 months of regular aerobic exercise resulted in “modest” waist size reductions of a little more than 1 inch in adults who were overweight or obese. 

The weekend warriors in the recent study did indeed work out harder and longer than those exercising throughout the week. In fact, they worked out for 147.6 minutes, on average, per session – well over 2 hours at a time. 

That part is key. In this and other studies, weekend warriors are, by definition, meeting or exceeding recommended exercise levels. They just happen to do it over fewer days.

“We don’t know that it’s the weekend pattern per se that is responsible for the findings rather than simply comparing 150 minutes accumulated in two versus three or more bouts of exercise with the same weekly total,” said Peter Hall, PhD, a professor of public health at the University of Waterloo, Ontario. 

Another caveat is the study design. “This is a cross-sectional study, and the researchers looked at associations between type of exercise patterns and obesity outcomes,” said Alexandra van den Berg, PhD, a professor of health promotion and behavioral sciences at the University of Texas. “This study design does not allow for the testing of causal relationships.”

That is, exercise was linked to lower body weight – but we can’t say for sure that exercise caused a lower body weight. What’s more, the NHANES data surveyed people only once and did not track them over time. The study authors acknowledge this limitation in their paper, stating they “cannot account for changes over time or the causal relationship between physical activity patterns and body fat reduction.”

Consider, too, that the weekend warriors tended to be younger than the other groups. Their average age was 35.9, while those who exercised throughout the week had an average age of 37.5, and those in the inactive group averaged 40.5 years old. 

The weekend warriors “may have been healthier than the traditional exercise group and the control group to start,” said Kimberley Dawson, PhD, a professor of sport and exercise psychology at Wilfrid Laurier University in Waterloo, Ontario. “Therefore, they didn’t need as much activity to make a difference.”

Still, the study authors suggest there could be more to it than that, saying that long weekend workouts may affect the body differently than more traditional exercise patterns. Previous studies have shown that short-term exercise may increase blood levels of stress hormones called catecholamines and boost blood flow through fat tissue, which could help the body burn more fat. 

But not everyone agrees. “It’s not the movement that will improve our health but rather the sedentariness that will decrease it,” Dawson said. “Sitting for five days and moving for two does not adequately decrease the lack of movement to gain physiological effects of movement.” 

At the same time, exercising less often might increase the risk of injury, Zhang warned. A 2014 study found that out of 351 adults who had a severe injury, 55% got hurt on the weekend, while 45% were injured between Monday and Friday. The authors suggested lack of experience and low fitness could be to blame, or it could be that more people take part in riskier sports on days they don’t have work. 

What This Means for You

If you want to make exercise work for weight loss, aim for 60 to 90 minutes of moderate physical activity most days – the amount recommended for weight loss

Keep in mind that doesn’t need to be done all at one time; you could do 20- to 30-minute bouts three times a day, for instance. 

Consider monitoring your diet as well. The weight loss plans that work the best combine better nutrition with an increase in physical activity, research shows.

If you only have weekends available to work out, expect to exercise long and hard during those sessions if you want to lose weight. (They’re called “warriors” for a reason!) 

“I would rather see individuals move as much as they can during the week and enjoy longer durations of exercise on weekends when their schedules permit it,” Dawson said. “From a behavior modification perspective, this approach will lead to sustained activity change.”

And regardless of when you choose to exercise, it may be wise to measure your expectations about weight. People tend to become discouraged when their true weight loss falls short of their hopes. Instead, focus on improving your quality of life and the health benefits – you’ll get those and a more capable body even if the scale doesn’t budge.



Source link

Preventing HIV During Pregnancy


In a large study conducted in South Africa, Uganda, and Zimbabwe both a vaginal ring containing the antiretroviral drug dapivirine (DVR) and daily oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine (Truvada) were each found to be safe for HIV prevention among cisgender women who started using 1 of them in their second trimester of pregnancy.1

Data from a phase 3b study, known as DELIVER, was designed to evaluate the safety and acceptability of the ring, as well as to collect additional safety data on the use of tenofovir disoproxil fumarate and emtricitabine during pregnancy. It was also designed to be conducted in stepwise fashion, enrolling 1 group at a time, beginning with women late in pregnancy, when the potential risks from drug exposure are lowest, and only proceeding to the next group if an independent review of study data deems it is safe to do so.2

The results of the study were reported at this week’s ongoing Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, CO.

According to the investigators, study participants were 18-40 years of age and randomized to receive either the ring or oral PrEP until delivery or 41 weeks and six days, whichever came first. Of 251 pregnancies, 1% experienced stillbirth or miscarriage, 95% of deliveries were at term and 4% were preterm.1

Four percent of live births had congenital anomalies, none of which were related to study products. These trends and other pregnancy complications occurred at a similar frequency to a reference dataset of more than 10,000 deliveries at the same hospitals and no study participants acquired HIV.1

The ring is made of flexible silicone, and continuously releases dapivirine. It is replaced monthly by the user. It is approved in several African countries and recommended by the World Health Organization for HIV prevention.1

The safety of oral PrEP with tenofovir disoproxil fumarate and emtricitabine has been well established among pregnant cisgender women with HIV taking them as part of a treatment regimen. Several country regulatory agencies have requested data on oral PrEP use during pregnancy for prevention to complement that evidence.

A woman’s risk of acquiring HIV during pregnancy is estimated to be up to 3 times higher compared to other periods in her life, and following pregnancy, when many women are breastfeeding, the risk is even greater.2

“Adverse pregnancy outcomes related to DVR and TDF/FTC use were uncommon in the second trimester of pregnancy, with rates similar to the communities where the study was conducted. These data, combined with the data from cohorts 1 and 2 and the safety data from women who used the DVR at the time of conception, support using DVR and TDF/FTC as HIV prevention,” the investigators wrote.3


References

1.Vaginal ring and oral pre-exposure prophylaxis found safe for HIV prevention throughout pregnancy. National Institutes of Health press statement. March 5, 2024. Accessed March 6, 2024.
https://www.nih.gov/news-events/news-releases/vaginal-ring-oral-pre-exposure-prophylaxis-found-safe-hiv-prevention-throughout-pregnancy

2. Parkinson J. No Safety Concerns With Dapivirine Ring in Third Trimester of Pregnancy. ContagionLive. February 21, 2023. Accessed March 6, 2024.
https://www.contagionlive.com/view/no-safety-concerns-with-dapivirine-vaginal-ring-in-third-trimester-of-pregnancy

3. Mhlanga F, Bunge K, Fairlie L, et al. Safety of Dapivirine Vaginal Ring and Oral PrEP for HIV Prevention in the Second Trimester. Poster #168 presented at CROI 2024. March 3-6, 2023. Denver, CO.



Source link

Spinach Pie Recipe | The Recipe Critic

0


This website may contain affiliate links and advertising so that we can provide recipes to you. Read my disclosure policy.

This savory spinach pie is packed with spinach and baked in a flaky crust. It’s loaded with three kinds of cheeses, onion, garlic, eggs, and seasoned with tons of flavor! Enjoy it warm or cold, and any time of day.

Spinach is such a versatile green and can be the star of the show in many different recipes! Try our favorite spinach salad, this tasty stuffed spinach chicken, or my creamy chicken and mushroom florentine over a bed of noodles.

Close view of a slice of spinach pie on a small white plate with a fork.

What is Spinach Pie?

Spinach pie is similar to classic Greek spanakopita. The difference is the crust, and you will love both versions! Spanikopita uses flakey fillo dough, and spinach pie is baked in a traditional pie crust. Spinach pie is savory and creamy and bursting with cheesy flavors. My recipe uses ricotta cheese, feta cheese, and parmesan cheese. Triple the cheese, making it 3 times as delicious! This spinach pie is so versatile and can be served for breakfast, lunch, or dinner. It’s also tasty warm or cold, so enjoy it anytime, anywhere, and at any temperature!

You can serve this as a side dish or as an entree. Go along with the Greek-inspired theme and enjoy it with Greek salad, this chicken, and of course baklava for dessert!

Ingredients in Spinach Pie

The ingredients to this are actually pretty simple! Gather them up and hurry and make this. Follow the recipe card below for exact measurements!

  • Pie Crust: Refrigerated pie crust makes this recipe so easy! Feel free to make your own if you have the time.
  • Olive Oil: Oil the skillet to help cook the onions, garlic, and spinach.
  • Yellow Onion: Minced onion is delicious in this pie.
  • Garlic: Fresh minced garlic adds so much flavor!
  • Spinach: Stems removed and chopped. Fresh spinach is best but see my tips for frozen spinach!
  • Parsley and Dill I use fresh parsley and dried dill for added flavor! You’re welcome to use all fresh or all dried. Whatever you can find.
  • Crumbled Feta Cheese: Don’t try and substitute this for another cheese. The feta is classic to this dish.
  • Ricotta Cheese: Adds a creamy and cheesy texture to the spinach pie.
  • Parmesan Cheese: Shredded parmesan cheese here.
  • Salt and Pepper: Season and balance all the flavors!
  • Large Eggs: The eggs bind all of the ingredients together.

Spinach Pie Recipe

You are going to love this spinach pie recipe. It is quick and easy and will surprise how flavor packed it is! All I can say is that you have to give it a try before you form an opinion because I know you’re going to LOVE it! Follow my step-by-step instructions below in the recipe card.

  1. Preheat Oven/ Prepare Pie Crust: Preheat the oven to 350 degrees Fahrenheit then line a 12-inch pie dish with the pie crust. Place it in the refrigerator to keep the pie crust cold while you prepare the filling.
  2. Saute the Onion, Garlic, and Spinach: In a large skillet over medium-high heat, saute the onion in the oil until the onion is tender. Add the spinach and garlic and saute until the spinach has wilted down. Remove the spinach and onion from the heat and set aside.
  3. Add the Cheeses, Seasonings, and Eggs: In a large bowl, whisk together the parsley, dill, feta, ricotta, parmesan, salt, pepper, and eggs.
  4. Stir in the Spinach Mixture: To the bowl add in the spinach mixture and mix thoroughly.
  5. Pour Into the Pie Crust: Remove the pie crust and pan from the fridge and fill it with the spinach filling.
  6. Bake: Bake the pie for 45-50 minutes, the top of the pie should start to turn a golden brown.
  7. Rest and Enjoy: Remove from the oven and allow it to rest for at least 5 minutes before serving.
First photo of the spinach, onion, and garlic sauteed in a pan. Second photo of the egg and cheese ingredients in a bowl. Third photo of the spinach mixture added to the cheese mixture. Fourth photo of the filling added to the pie dish.

Tips and Variations

I have some tips and variations below for when you make this spinach pie! I hope you find them helpful because I want this recipe to be a success for you.

  • Cheese: Switch out the parmesan cheese if you want to experiment. I think mozzarella or pepper-jack cheese would be so tasty in this recipe. You can also use cottage cheese in place of ricotta cheese if you’re in a pinch. I would stick to full-fat though!
  • Spinach: You can use frozen spinach. Thaw 10 ounces of frozen spinach, thaw it, then thoroughly squeeze out any liquid before using.
  • Pie Dish: I used a deep pie dish to fit the filling. If your pie dish is shallow, I’d suggest using a bigger pie dish.

Top view of the baked spinach pie in a white pie dish.

How to Store Leftovers

Leftover spinach pie is delicious the next day because you can enjoy it for breakfast, lunch, or dinner! Here is how you can store it for later.

  • In the Refrigerator: Once your spinach pie has cooled, then place it in an airtight container in the refrigerator. It will last about 3-5 days.
  • To Reheat: You can reheat this in the oven at 325 degrees Fahrenheit for about 15 minutes or until warmed through.

Close side view of a gold serving spatula holding up a slice of pie.

More Savory Pies To Make

Pin this now to find it later

Pin It

  • Preheat the oven to 350 degrees Fahrenheit then line a 9-inch pie dish with the pie crust. Place it in the refrigerator to keep the pie crust cold while you prepare the filling.

  • In a large skillet over medium high heat, saute the onion in the oil until the onion is tender. Add the spinach and garlic and saute until the spinach has wilted down. Remove the spinach and onion from heat and set aside.

  • In a large bowl, whisk together the parsley, dill, feta, ricotta, parmesan, salt, pepper, and eggs.

  • To the bowl add in the spinach mixture and mix thoroughly.

  • Remove the pie crust and pan from the fridge and fill it with the spinach filling.

  • Bake the pie for 45-50 minutes, the top of the pie should start to turn a golden brown.

  • Remove from the oven and allow it to rest at least 5 minutes before serving.

Calories: 363kcalCarbohydrates: 21gProtein: 18gFat: 24gSaturated Fat: 10gPolyunsaturated Fat: 2gMonounsaturated Fat: 10gTrans Fat: 0.01gCholesterol: 102mgSodium: 914mgPotassium: 777mgFiber: 3gSugar: 1gVitamin A: 7642IUVitamin C: 27mgCalcium: 529mgIron: 7mg

Nutrition information is automatically calculated, so should only be used as an approximation.





Source link

Healthy You! – March 2024 edition

0


With spring right around the corner, the March edition of Healthy You! highlights the benefits of embracing change. Your employees will learn how to view change as an opportunity for growth and empowerment. They can discover how focusing on the five components of fitness can help improve their strength and conditioning. And there is important information about how making small changes to daily routines can reduce the risk for developing type 2 diabetes.

Read the new issue.



Source link

Is the Faith in Aspirin to Prevent Cardiac Events Warranted?


March 5, 2024 — There’s a widespread – and long-held — belief that swallowing a low-dose aspirin pill every day can help protect you from heart attacks and strokes. 

Almost 30 million Americans take aspirin to prevent a first cardiovascular event (“primary prevention”), and nearly 40% of those over 50, around 49 million people, are taking aspirin either for primary prevention or for secondary prevention after they’ve had a stroke or a heart attack.

However, experts have begun to question aspirin’s effectiveness, prompting health care professionals to reevaluate the role of aspirin in primary prevention. 

In 2019,  the American College of Cardiology/American Heart Association primary prevention guideline, the most recent one available, said aspirin “should be used infrequently” in the routine primary prevention of a type of cardiovascular disease because of lack of net benefit.” 

This recommendation was made after weighing the benefit of aspirin use in primary prevention against the risk of bleeding in the brain and the digestive tract. The results of three major clinical trials published in 2018 had a major influence on the guideline, said cardiologist John W. McEvoy, MBBCh, one of the guideline’s co-authors and a professor of preventive cardiology at the National University of Ireland in Galway.

“Our initial take on the evidence was that it didn’t support significant efficacy for aspirin in preventing heart disease and stroke and that the risk of bleeding probably outbalanced the benefit,” he said.

On the other hand, McEvoy said, the guideline also says that “every patient needs to have an individualized decision on aspirin. It’s not one size fits all. We didn’t say not to give aspirin to anyone because we felt there were some high-risk patients who might benefit.”

Age-Based Recommendations

The United States Preventive Services Task Force, a nongovernmental advisory group, has also weighed in on the role of aspirin in primary prevention. In 2022, the task force updated its 2016 recommendation after a systematic review of the evidence. The group said aspirin use has a “small net benefit” for primary prevention of cardiovascular events, but only in adults aged 40-59 who have a 10% or greater risk of a cardiovascular event within 10 years. It recommended against adults 60 years or older taking aspirin, saying “it has no net benefit.”

Explaining its advice for older people, the the task force said the aspirin-related risk of gastrointestinal or brain bleeding, and stroke increases with age.

Not many studies have been done on the risk-benefit question of aspirin use in older adults. But a secondary analysis of data from one of the 2018 studies that were crucial in the American College of Cardiology/American Heart Association guideline indicates that the risk of brain bleeding is significant in people over 70, while there is no benefit of aspirin for primary prevention of stroke in this population.

All of the 19,114 participants in the study, conducted in Australia and the U.S., were healthy people with a median age of 74. Half of them got aspirin, and the other half got a placebo. 

Aspirin didn’t produce a statistically significant reduction in the rate of ischemic stroke (the most common kind). But there was a significant increase in bleeding in the brain among those taking aspirin compared to those getting the placebo. 

Lead author John J. McNeil, PhD, professor of epidemiology and preventive medicine at Monash University in Melbourne, Australia, said both brain bleeds and hemorrhagic strokes were more frequent in the aspirin group, and that the frequency of falls among older people increased the probability of these events.

“Most of these hemorrhages occur in people who fall and bang their heads, and we speculated that many of those people hit their head when they fall,” he said.

Reduced Risk of CVD

The original studies on the benefits of aspirin in primary and second prevention of cardiovascular were done several decades ago. Today, the effectiveness of aspirin may have declined because some risk factors are better controlled than they once were, said Anum Saeed, MD, assistant professor of medicine at the University of Pittsburgh School of Medicine and a cardiologist at UPMC Heart and Vascular Institute. For example, she said, we now have statin drugs to reduce LDL cholesterol (the bad kind) and effective medications to lower blood pressure.

Saeed carefully weighs the risk factors of patients before starting them on aspirin for primary prevention. Among those who she would advise to take aspirin, she said, are people with high amounts of calcium in the coronary artery, people who have diabetes, and patients who have high LDL cholesterol. 

However, she advises people to control their risk factors before starting to take aspirin, she added. She recommends that they reduce their blood pressure and cholesterol, exercise regularly, and improve their diet, among other things. 

If they have no risk factors for cardiovascular disease, she won’t put them on aspirin. If they’re over 70, have significant risk factors, and have been taking aspirin for some time with no problems, she recommends that they continue taking it. But she keeps a close eye on these patients, making sure they’re not at risk for falls, for example.

McEvoy, likewise, tries to get patients’ risk factors under control before discussing aspirin with them. If their risk of CVD is low, he’ll tell them they don’t need aspirin. With people over 70, he highlights the risks of aspirin to a greater extent.

Discontinuing Aspirin May Pose Risks

Should older people who have been on aspirin for years continue taking it for primary prevention? That’s a surprisingly difficult question to answer. 

In a recent paper, McEvoy and his colleagues tried to solve the question by examining combined data from the 2018 aspirin trials. What they found is that, of the 15% of study participants who were taking aspirin before the trial, fewer of those who kept taking it during the study had heart attacks or strokes than of those who received a placebo instead. 

A couple of observational studies had similar results, leading McEvoy to believe that people who take aspirin for primary prevention and then discontinue it are at slightly higher risk of cardiovascular events than those who keep taking it.

Nevertheless, he always discusses the pros and cons of continuing aspirin use with his older patients. 

“There are patients who have been taking aspirin for years and who have never had a problem with aspirin. They don’t have any history of dyspepsia or GI bleeding, and don’t have risk factors for bleeding in terms of falls or use of other medications that can increase risk.”

Before he has these patients stop taking aspirin, he talks to them. 

“I say, ‘There’s mixed evidence. As you get older, the risk of bleeding will become higher, but we also know that aspirin can reduce nonfatal cardiovascular disease,’” he said.

Some patients feel strongly about their risk of heart disease or stroke to the point they worry about that over the bleeding risk. “In those patients, I don’t necessarily stop aspirin,” McEvoy said. “But I do weigh the risk factors, and if they have other risk factors, I tell them that aspirin may not be necessary.”



Source link

Healthy Trader Joe’s Shopping List

0


Sharing some of my favorite healthy products from Trader Joe’s!

Hi friends! How are ya? I hope you’re having an amazing day! I have some calls this morning, and then am getting a massage… can’t.wait.

For today’s post, I wanted to share some of my favorite healthy finds from Trader Joe’s! During the time-that-shall-not-be-named, the Pilot did all of our grocery shopping because he was “out in the world” and the girls and I were at home. We also got a lot of grocery delivery from Whole Foods and Thrive Market. It kind of stuck around for years after that, until I realized that I actually love grocery shopping and had missed it. So now, we alternate, since we both like going to the store in person — you find so many more fun things that way!

Trader Joe’s has some amazing things, and here are some of my favorite healthier finds. While I believe that ALL foods should fit into your lifestyle, this is a list of things that have less ingredients and offer more on the nutritional front (with a few of the soul-hugging must-haves in here, too).

Here’s the list!

Healthy Trader Joe’s Shopping List

PRODUCE/COLD:

– Organic fruit: we go for berries, bananas, grapes, apples, and anything seasonal and exciting, like cherries, melon, stone fruits, or rambutan

– Organic veggies: sweet potatoes, zucchini, celery, carrots, bell peppers, squash

– Edamame

– Root vegetable hash

– Cold-pressed green juice

– Mirepoix (makes soups and casseroles SO easy)

– Onions, garlic, and ginger

– Medjool dates

– Organic guacamole

– Salsa! We love their pico and their Salsa Especial

BEANS, SPICES, PANTRY STAPLES:

– ALL organic beans: each week, I get white beans, kidney beans, black beans, and garbanzo beans

– Organic chicken broth

– Organic jasmine rice

– Organic pasta from Italy

– ALL the spices! We love their oregano, basil, thyme, rosemary, garlic powder, and Everything But the Bagel seasoning

– Canned tuna, sardines, anchovies

– Almond butter

– Organic peanut butter

– Organic raspberry or strawberry preserves

– Chocolate chips

– Maple syrup

– Oatmeal

– Canned tomatoes

– Olives

– Artichokes

BARS + SNACKS:

– Date and Chocolate bars

– Trail mix

– Chomps jerky

– Organic dried fruit and fruit leather

DAIRY + EGGS:

– Kerrygold unsalted butter

– Almond milk

– Full fat organic Greek yogurt

– Organic cheese sticks

– Raw or aged cheeses; their parm is amazing

– Organic pasture-raised eggs (I prefer the Vital Farms eggs from Whole Foods but these work in a pinch)

FROZEN + SWEET TREATS:

– Hold the cone! Vegan mini ice creams. These are SO good and the perfect size for a sweet bite

– Gone Bananas or Gone Berry Crazy ; fruit simply covered in chocolate and frozen!

– Organic frozen berries mix; perfect for smoothies

– Cauliflower rice; love this for soups, smoothies, and scrambles

– Almond flour chocolate chip cookies mix

BREAD + TORTILLAS:

– Corn tortillas

– Sourdough bread for sandwiches

– A sweet treat! They often have gluten-free dessert options with fairly simple ingredients

MEAT:

– We typically get all of our meat from Butcher Box and Whole Foods, but I do like Trader Joe’s organic chicken thighs and organic deli meat

I think that’s it! I just wrote that list off the top of my head with things we always buy!

Do you have any Trader Joe’s faves? Where do you get most of your groceries?

Here’s a list of my Favorite Trader Joe’s products.

Have a great day and I’ll see ya soon!
xoxo

Gina

For more healthy meal ideas and recipes, download my free meal plan and recipe pack for busy friends! They’re all quick and healthy meals you can make in a snap.



Source link

Remdesivir Associated With Lower Risk of Long COVID in Hospitalized Patients


A new study showed that patients hospitalized for acute COVID-19 infection, and were treated with remdesivir (Veklury, Gilead), experienced a reduced risk of symptoms related to post-acute Sequelae of SARS-CoV-2 (PASC) or Long COVID. According to the investigators, the positive effect tended to be stronger in the younger age group.

“RDV treatment during the first 2 days of hospitalization (vs no RDV treatment during the first 2 days of hospitalization) was associated with lower relative hazards for any PCC symptom/ diagnosis in patients aged <65 years (HR, 0.90 [95% CI, 0.86-0.93];) and in patients aged ≥65 years (HR, 0.90 [95% CI, 0.86-0.95],” the investigators wrote.

This new data was reported at this week’s ongoing Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, CO.

Remdesivir is an intravenous antiviral, and was FDA approved for the treatment of COVID-19 in nonhospitalized patients at high risk of progression to severe disease and in hospitalized patients.

Study Methods

Investigators performed a retrospective cohort study with information from HealthVerity database. Study participants included individuals 12 years of age and older who were hospitalized for COVID-19 for 2 days or more during a study period between May 1, 2020, and September 30, 2021. Remdesivir exposure was measured on day 1 or 2 of hospitalization, and symptoms and diagnoses associated with Long COVID occurred 90 to 270 days post hospitalization.

Long COVD is characterized by a myriad of symptoms, and for the purposes of this study, they included:

  • Cognitive dysfunction
  • Cerebrovascular disease
  • Neuropsychiatric features
  • Diarrhea
  • Thromboembolic disease
  • Chest pain
  • Ischemic heart disease
  • Headache
  • Dysautonomia
  • Fatigue
  • Smell disturbance/anosmia
  • Muscle pain/myalgia
  • Taste disturbance/ dysgeusia/ageusia
  • Dyspnea/breathlessness
  • Joint pain/arthralgia
  • Cough

Takeaways

Remdesivir treatment was also associated with a reduced risk of several of the individual symptoms/diagnoses.

“RDV was associated with lower hazards for 8/16 individual possible PCC-related symptoms/ diagnoses in the <65 years age group and 6/16 individual possible PCC-related symptoms/diagnoses in the ≥65 years age group,” the investigators wrote.

As Long COVID continues to remain a mystery in terms of its pathophysiology and duration, prevention modalities are significant opportunities to reduce its incidence rates and severity. 

Reference
Berry M, Kong A, Paredes R et al. Effect of Remdesivir on Post-COVID Conditions Among Individuals Hospitalized With COVID-19 by Age. More PCC-related symptoms and diagnoses were impacted by RDV treatment, and the effect size tended to be stronger, in the younger age group. Abstract was presented at CROI 2024. March 3-6, 2023. Denver, CO.



Source link

Poffertjes | The Recipe Critic

0


This website may contain affiliate links and advertising so that we can provide recipes to you. Read my disclosure policy.

Poffertjes are small, fluffy Dutch pancakes that are so delicious for breakfast! Serve them with a dusting of powdered sugar and fresh berries for a meal that everyone will love.

I’m always looking for recipes that make breakfast fun and unique! These Poffertjes definitely fit the bill! If you’re looking for other options to complete your brunch spread, try twisted bacon, baked scrambled eggs, air fryer sausage, and creamy poppy seed fruit salad.

What are Poffertjes?

Poffertjes make such a fun breakfast, snack or dessert! These light and airy mini pancakes are common street food in Amsterdam. They’re super easy to make too! A simple pancake batter is cooked on each side until golden and served warm with a sprinkle of powdered sugar.

Poffertjes are often confused with ebelskivers, and although they are very similar, there are a few differences. Poffertjes rely on active yeast as a leavening agent, whereas ebelskivers use baking powder and baking soda, making the poffertjes a little yeasty. Ebleskivers are rounder and can be filled with chocolate and jams, poffertjes are shallower and can’t be filled. Kids really have fun with Poffertjes because they look like baby pancakes, and we all go crazy for their wonderful flavor and melt-in-your-mouth texture.

Ingredients Needed

This Poffertjes recipe might look fancy but it uses common ingredients that you probably have in your pantry right now.

  • Milk: Warmed milk helps to activate the yeast and gives the batter a perfect consistency.
  • Instant Yeast: Ensures these pancakes puff up with a fluffy texture.
  • Sugar: For just enough sweetness.
  • All-Purpose Flour: Gives the pancakes structure and tenderness.
  • Salt: A small amount to enhance the flavor.
  • Egg: To bind the ingredients and ensure the pancakes cook properly.
  • Butter: To grease the pan.
  • Powdered Sugar: Finish these with a dusting before serving for a pretty presentation and extra sweetness.

How to Make Poffertjes

These look like they might be complicated to make but they’re quite simple. If you have a poffertjes pan that’s really convenient to use but a large skillet works too!

  1. Activate the Yeast: In a medium bowl, whisk together the milk, yeast, and sugar. Let the mixture rest until the yeast becomes frothy, about 5 minutes.
  2. Combine all Ingredients: In a large bowl, whisk together the flour and salt. When the yeast mixture is ready, pour it into the bowl of flour along with the egg.
  3. Mix: Use an electric hand mixer and beat the batter until it is smooth. You can also use a whisk but an electric mixer is quicker.
  4. Let Rest: Cover the batter and let it rest for 45 minutes to an hour, the batter should become very bubbly and double in size.
  5. Cook: Heat a poffertjes pan or large skillet over medium heat. Grease each cup or the surface of the skillet with some of the butter and scoop a heaping tablespoon of batter into each cup. If using a skillet leave a couple inches of space between each poffertjes.
  6. Flip: Flip the poffertjes after about 2 minutes of cooking, bubbles should form on the top of the uncooked batter.
  7. Continue to Cook: Cook another 1-2 minutes until they are all golden brown on both sides then remove from the pan and continue with the rest of the batter.
  8. Serve: Enjoy fresh dusted with some powdered sugar and your favorite sweet breakfast sides!

Tips and Variations

To ensure your Poffertjes bake up perfectly, here are a few tips and tricks! Our whole family loves these, and I know your family will love them too!

  • Use Buckwheat Flour: Poffertjes are traditionally made with 1 part all purpose flour and 1 part buckwheat flour, you can try making the recipe this way if you have buckwheat flour!
  • Size: Use a heaping tablespoon of batter for each Poffertjes. This will make enough to serve 8 people.
  • To Keep Warm: If you are cooking in batches and need to keep some warm while others are still cooking, place the mini pancakes on a baking sheet in a single layer and keep warm in the oven at 200 degrees Fahrenheit until ready to serve.
  • Clean the Pan: If you’re using a skillet to cook the poffertjes, try to wipe off the excess butter for the next batch of mix to be cooked. This will make sure the pancakes turn out golden brown and perfectly cooked each time.
  • Add More Flavor: To give these extra flavor, try adding a teaspoon or two of vanilla extract or almond extract.

Storing Leftovers

These incredible Poffertjes are easy to make and super fun eat! They taste best fresh, but if you have some leftovers, here is how to store them.

In the Refrigerator: Transfer them to an airtight container and store them in the refrigerator for up to 5 days.

More Delicious Breakfast Recipes

Breakfast is the most important meal of the day! Whether you love sweet or savory options best, we have plenty of morning meal ideas to choose from. There’s something for everyone from pancakes to quiche and more! Here are a few of our favs:

Pin this now to find it later

Pin It

  • In a medium bowl, whisk together the milk, yeast, and sugar. Let the mixture rest until the yeast becomes frothy, about 5 minutes.

  • In a large bowl, whisk together the flour and salt. When the yeast mixture is ready, pour it into the bowl of flour along with the egg.

  • Use an electric hand mixer and beat the batter until it is smooth. You can also use a whisk but an electric mixer is quicker.

  • Cover the batter and let it rest for 45 minutes to an hour, the batter should become very bubbly and double in size.

  • Heat a poffertjes pan or large skillet over medium heat. Grease each cup or the surface of the skillet with some of the butter and scoop a heaping tablespoon of batter into each cup. If using a skillet leave a couple inches of space between each poffertjes.

  • Flip the poffertjes after about 2 minutes of cooking, bubbles should form on the top of the uncooked batter.

  • Cook another 1-2 minutes until they are all golden brown on both sides then remove from the pan and continue with the rest of the batter.

  • Serve fresh dusted with some powdered sugar and your favorite sweet breakfast sides!

Store leftovers in the fridge in an airtight container for up to 5 days.
Poffertjes are traditionally made with 1 part all purpose flour and 1 part buckwheat flour, you can try making the recipe this way if you have buckwheat flour!
What’s the difference between Poffertjes and ebelskivers?
Poffertjes rely on active yeast as a leavening agent whereas ebelskivers use baking powder and baking soda, making the poffertjes a little yeasty. Ebleskivers are rounder and can be filled with chocolate and jams, poffertjes are shallower and can’t be filled.

Serving: 1servingCalories: 167kcalCarbohydrates: 31gProtein: 5gFat: 2gSaturated Fat: 1gPolyunsaturated Fat: 0.3gMonounsaturated Fat: 1gTrans Fat: 0.003gCholesterol: 26mgSodium: 99mgPotassium: 111mgFiber: 1gSugar: 7gVitamin A: 104IUCalcium: 64mgIron: 2mg

Nutrition information is automatically calculated, so should only be used as an approximation.





Source link

Thunderstorm Asthma Could Strike More Often With Climate Change


March 5, 2024 — Thunderstorm asthma can strike with little warning, leaving people with the symptoms of an asthma attack during or after the dark clouds pass. 

If you’re unfamiliar, the risk for a thunderstorm asthma attack grows when heavy storms arrive on a day with very high pollen or spores. The storm uplifts these particles, adds water, and causes them to explode into smaller grains. The electrical activity in a storm can do the same. Next, strong winds sweep these particles down and across the ground. People in the path of the storm can experience shortness of breath, coughing, and wheezing.

If thunderstorms are predicted to become more frequent and more severe with climate change, will the same hold true for thunderstorm asthma?   

“Yes, if only because the amount of pollen appears to be increasing in many areas due to climate change,” said Frank S. Virant, MD, chief of the Allergy Division at Seattle Children’s Hospital.

Most cases of thunderstorm asthma occur in the spring and early summer, but that also could change. Pollen seasons “have been getting longer and more intense,” said Shaan M. Waqar, MD, an allergist at ENT and Allergy Associates in Plainview, NY. 

“Thunderstorm asthma events are rare, but our changing environment and the increase in the number of people with allergies may make such events more common and more severe into the future,” agreed Paul J. Beggs, PhD, associate professor in the School of Natural Sciences at Macquarie University in Sydney, Australia.

How to Minimize Your Risk

If you’re sensitive to pollen, continue to monitor outdoor levels, particularly during tree, grass, and weed pollen season, Virant recommended. Also pay attention to weather reports. Watch for thunderstorms that could “amplify exposure to the pollen with 40-plus mile per hour winds and often colder air downdrafts.” Cold is an additional asthma trigger, he noted. 

People with asthma should try to stay indoors with windows and doors closed during strong thunderstorms and for several hours afterwards. Using air filters can also help reduce risk, said Deepti V. Manian, MD, an allergist and immunologist at Stormont Vail Health in Topeka, KS. 

Continue controller therapies — such as longer-acting inhalers and allergy medications — and use a rescue inhaler or nebulizer for prompt treatment of symptoms, recommended Donald J. Dvorin, MD, of The Allergy and Asthma Doctors in Mount Laurel, NJ. Ideally, people seeking shelter indoors during storms should be “accompanied by friends or family who can help them transport quickly to a hospital if needed.”

Asthma Diagnosis Not Required

Even people who would not consider themselves to have asthma can be seriously affected. For example, people with hay fever, or allergic rhinitis as it’s also known, are also at risk, said Ajay Kevat, MBBS, MPH, of the respiratory department at Queensland Children’s Hospital in Brisbane, Australia.

People with hay fever can also experience stronger symptoms during and after thunderstorms. Optimally treating allergic rhinitis during the pollen season with non-sedation antihistamines and nasal steroids can help, Virant said, instead of “chasing symptoms with medication after they are already severe.” 

Part of the challenge is connecting severe weather to worse asthma symptoms. “In my experience, there is a lack of awareness surrounding thunderstorm asthma,” Manian said. For example, people with non-allergic rhinitis, also known as vasomotor rhinitis, can also experience the effects. “It often surprises many of my patients when I introduce the concept of vasomotor rhinitis, which can be triggered by environmental fluctuations.”

Gathering Clouds, Gathering Evidence

Climate change could also change which Americans experience the most storms. Researchers in a June 2022 study predicted fewer storms in the Southern plains and more storms in the Midwest and the Southeastern United States in the future.

Dvorin practices in Southern New Jersey, and in this area, “we fortunate in this area not to experience thunderstorm-induced asthma exacerbations,” he said. 

But climate change means that in the future, thunderstorm asthma could strike in places it has never been seen before, said Kevat, who wrote a thunderstorm asthma review article published online June 2020 in the Journal of Asthma and Allergy.

And this is not just a concern in the United States. Major thunderstorm asthma events have been reported in Italy, the United Kingdom, the Middle East, Asia, and Australia. In  November 2016, for instance, a strong set of storms swept across Melbourne, Australia. Temperatures dropped 10C (about 18F), humidity rose above 70%, and particulate matter like pollen became more concentrated in the air. 

This event spurred a “thunderstorm asthma epidemic of unprecedented magnitude, tempo, and geographical range and severity,” Beggs and colleagues wrote in their June 2018 report in The Lancet Planetary Health

Large-scale events like this can affect entire communities and quickly overwhelm local health care resources. Within 30 hours of the Melbourne storms, 3,365 people more than usual came to local emergency departments with respiratory issues — and 476 with asthma were admitted to the hospital. Ten people died: five in the hospital and five who could not be resuscitated or died while waiting for emergency services.

More research is needed “so as to best prepare for this unpredictable, significant public health threat,” Kevat wrote.

People whose asthma is triggered by pollen or mold spores are particularly at risk for thunderstorm asthma, Waqar said. If you’re unsure, an allergist can help diagnose and treat your allergic risks.

More severe thunderstorms are just one asthma trigger associated with climate change. Last summer, Canadian wildfires sent smoke across the northern U.S. and triggered widespread asthma exacerbations. See the WebMD slideshow to learn more about how rain, humidity, and seasonal weather changes can also present asthma challenges. 



Source link

The Role of Bulevirtide in Chronic Hepatitis D with HIV and HBV


Bulevirtide (BLV), an entry inhibitor sanctioned by the European Union for chronic hepatitis D (CHD) therapy, has scant evidence regarding its safety and effectiveness in individuals coinfected with HIV, HBV, and HDV. This analysis at week 96 from the phase 3 MYR301 (NCT03852719) study seeks to outline the safety profile and effectiveness of BLV, specifically including patients with HIV/HBV/HDV co-infections. Both virologic and biochemical response rates improved, presenting no new safety concerns. The 2 patients co-infected with HIV/HBV/HDV experienced a comprehensive response and showed good tolerance towards BLV.

A total of 150 individuals with CHD were divided equally into 3 arms. Arm A received no active treatment against HDV for the first 48 weeks, then was administered 10mg/d of BLV for the subsequent 96 weeks (n=51). Arms B or C commenced treatment with BLV immediately at doses of 2 mg/d (n=49) and 10 mg/d (n=50) respectively, for 144 weeks, followed by a 96-week observation period post-treatment.

By week 96, combined, virological, and biochemical response rates were comparably effective in Arms B and C. For Patient 1, key metrics shifted from a baseline HDV RNA of 3,345,358 IU/mL to <50, HBV DNA from 22 IU/mL to undetectable, HBsAg from 18,000 to 6,400 IU/mL, and ALT from 289 to 18 U/L. For Patient 2, significant changes were noted from baseline to Week 96 in HDV RNA (from 425,354 IU/mL to <50), HBV DNA (from 17 IU/mL to <10), HBsAg (from 8,100 to 5,200 IU/mL), and ALT (from 97 to 26 U/L). By Week 96, both patients co-infected with HIV/HBV/HDV achieved a combined virological and biochemical response without necessitating any adjustments to their antiretroviral therapy regimen.

Initially, Patient 1, in Arm B was 39 years old, tested negative for HCV antibodies, had an undetectable HIV viral load, a CD4 count of 786/mm^3, and was on a regimen of tenofovir, lamivudine, and etravirine. Patient 2, in Arm C, was 40 years old, positive for HCV antibodies (but HCV RNA negative), had an undetectable HIV viral load, a CD4 count of 559/mm^3, and was on a treatment regimen of emtricitabine, tenofovir alafenamide, and raltegravir.

The efficacy of the treatments was evaluated based on a combination of criteria, including undetectable HDV RNA or a decline of ≥2 log10 IU/mL from baseline and normalization of ALT levels, alongside virologic and biochemical response rates. Controlled HIV infection was defined for this analysis as having a CD4 count >500 cells/mL and an undetectable HIV RNA level.

Across the board, initial characteristics were broadly consistent among the groups: average (SD) age stood at 41.8 (8.4) years, with males comprising 57%, Whites 83%, and those with compensated cirrhosis making up 47%. Average (SD) levels were HDV RNA at 5.05 (1.34) log10 IU/mL, ALT at 110.9 (69.0) U/L, and 61% were receiving concurrent nucleos(t)ide analogues.

Overall, neither of the HIV/HBV/HDV co-infected participants experienced any drug discontinuations, serious adverse events, or deaths related to BLV. Further research is warranted to explore BLV’s impact on patients with HIV/HBV/HDV co-infection and can be heard at the Conference on Retroviruses and Opportunistic Infections (CROI).

Reference

Wedemeyer H, Aleman S, Brunetto M, Wyles D, et. al. Efficacy and Safety of BLV 2 or 10 mg for 96 Weeks in CHD Including in 2 Patients With HIV/HBV/HDV. Poster #735 presented at CROI 2024. March 3-6, 2023. Denver, CO.



Source link

Daily Dose of Insights

Get a daily infusion of knowledge with our latest blog updates.

We don’t spam! Read our privacy policy for more info.